北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 期刊论文
学科主题: 基础医学
题名:
Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery
作者: Sun, Kai; Wang, Chuan-She; Guo, Jun; Horie, Yoshinori; Fang, Su-Ping; Wang, Fang; Liu, Yu-Ying; Liu, Lian-Yi; Yang, Ji-Ying; Fan, Jing-Yu; Han, Jing-Yan
关键词: Panax notoginseng ; microcirculatory disturbance ; leukocyte adhesion molecules ; hydrogen peroxide ; mast cell degranulation ; lipopolysaccharide
刊名: LIFE SCIENCES
发表日期: 2007-07-19
DOI: 10.1016/j.lfs.2007.06.008
卷: 81, 期:6, 页:509-518
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; HEPATIC MICROVASCULAR DYSFUNCTION ; LEUKOCYTE-ENDOTHELIAL ADHESION ; CELLS IN-VITRO ; PANAX-NOTOGINSENG ; ALKALINE-PHOSPHATASE ; HYDROGEN-PEROXIDE ; ACTIVE SAPONINS ; SEVERE SEPSIS ; SEPTIC SHOCK
英文摘要:

Ginsenoside Rb1 (Rb1). ginsenoside Rg1 (Rg1), and notoginsenoside R1 (R1) are major active components of Panalc notoginseng, a Chinese herb that is widely used in traditional Chinese medicine to enhance blood circulation and dissipate blood stasis. To evaluate the effect of these saponins on microcirculatory disturbance induced by lipopolysaccharide (LPS), vascular hemodynamics in rat mesentery was observed continuously during their administration using an inverted microscope and a high speed video camera system. LPS administration decreased red blood cell velocity but Rb1, Rg1, and RI attenuated this effect. LPS administration caused leukocyte adhesion to the venular wall, mast cell degranulation, and the release of cytokines. Rb1, Rg1, and R1 reduced the number of adherent leukocytes, and inhibited mast cell degranulation and cytokine elevation. In vitro experiments using flow cytometry further demonstrated that a) the LPS-enhanced expression of CD11b/CD 18 by neutrophils was significantly depressed by Rb1 and R 1, and b) hydrogen peroxide (H2O2) release from neutrophils in response to LPS stimulation was inhibited by treatment with Rg1 and R1. These results suggest that the protective effect of Rb1 and RI against leukocyte adhesion elicited by LPS may be associated with their suppressive action on the expression of CD11b/CD 18 by neutrophils. The protective effect against mast cell degranulation by Rb1 and R1, and the blunting of H2O2 release from neutrophils by Rg1 and R1 suggest mechanistic diversity in the effects of Panax notoarnseng saponins in the attenuation of microcirculatory disturbance induced by LPS. (c) 2007 Published by Elsevier Inc.

语种: 英语
WOS记录号: WOS:000248983700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55030
Appears in Collections:基础医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
2.Peking Univ, Dept Integrat Chinese & Western Med, Sch Basic Med Sci, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Kai,Wang, Chuan-She,Guo, Jun,et al. Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery[J]. LIFE SCIENCES,2007,81(6):509-518.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, Kai]'s Articles
[Wang, Chuan-She]'s Articles
[Guo, Jun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, Kai]‘s Articles
[Wang, Chuan-She]‘s Articles
[Guo, Jun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace