IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery
Sun, Kai; Wang, Chuan-She; Guo, Jun; Horie, Yoshinori; Fang, Su-Ping; Wang, Fang; Liu, Yu-Ying; Liu, Lian-Yi; Yang, Ji-Ying; Fan, Jing-Yu; Han, Jing-Yan
关键词Panax Notoginseng Microcirculatory Disturbance Leukocyte Adhesion Molecules Hydrogen Peroxide Mast Cell Degranulation Lipopolysaccharide
刊名LIFE SCIENCES
2007-07-19
DOI10.1016/j.lfs.2007.06.008
81期:6页:509-518
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; HEPATIC MICROVASCULAR DYSFUNCTION ; LEUKOCYTE-ENDOTHELIAL ADHESION ; CELLS IN-VITRO ; PANAX-NOTOGINSENG ; ALKALINE-PHOSPHATASE ; HYDROGEN-PEROXIDE ; ACTIVE SAPONINS ; SEVERE SEPSIS ; SEPTIC SHOCK
英文摘要

Ginsenoside Rb1 (Rb1). ginsenoside Rg1 (Rg1), and notoginsenoside R1 (R1) are major active components of Panalc notoginseng, a Chinese herb that is widely used in traditional Chinese medicine to enhance blood circulation and dissipate blood stasis. To evaluate the effect of these saponins on microcirculatory disturbance induced by lipopolysaccharide (LPS), vascular hemodynamics in rat mesentery was observed continuously during their administration using an inverted microscope and a high speed video camera system. LPS administration decreased red blood cell velocity but Rb1, Rg1, and RI attenuated this effect. LPS administration caused leukocyte adhesion to the venular wall, mast cell degranulation, and the release of cytokines. Rb1, Rg1, and R1 reduced the number of adherent leukocytes, and inhibited mast cell degranulation and cytokine elevation. In vitro experiments using flow cytometry further demonstrated that a) the LPS-enhanced expression of CD11b/CD 18 by neutrophils was significantly depressed by Rb1 and R 1, and b) hydrogen peroxide (H2O2) release from neutrophils in response to LPS stimulation was inhibited by treatment with Rg1 and R1. These results suggest that the protective effect of Rb1 and RI against leukocyte adhesion elicited by LPS may be associated with their suppressive action on the expression of CD11b/CD 18 by neutrophils. The protective effect against mast cell degranulation by Rb1 and R1, and the blunting of H2O2 release from neutrophils by Rg1 and R1 suggest mechanistic diversity in the effects of Panax notoarnseng saponins in the attenuation of microcirculatory disturbance induced by LPS. (c) 2007 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000248983700009
引用统计
被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55030
专题北京大学基础医学院
作者单位1.Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
2.Peking Univ, Dept Integrat Chinese & Western Med, Sch Basic Med Sci, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100871, Peoples R China
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GB/T 7714
Sun, Kai,Wang, Chuan-She,Guo, Jun,et al. Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery[J]. LIFE SCIENCES,2007,81(6):509-518.
APA Sun, Kai.,Wang, Chuan-She.,Guo, Jun.,Horie, Yoshinori.,Fang, Su-Ping.,...&Han, Jing-Yan.(2007).Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery.LIFE SCIENCES,81(6),509-518.
MLA Sun, Kai,et al."Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery".LIFE SCIENCES 81.6(2007):509-518.
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