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学科主题: 药学
题名:
Comparative study of the contents of analogues of aristolochic acid in two kinds of Aristolochiae Fructus by high-performance liquid chromatography
作者: Xu, Yu-Qiong2,3; Li, Xiao-Wei1,2; Liu, Guang-Xue2; Wang, Xuan1; Shang, Ming-Ying2; Li, Xiao-Mei4; Cai, Shao-Qing2,5
关键词: Madouling ; Aristolochia contorta ; Aristolochia debilis ; Aristolochic acid ; Aristololactam
刊名: JOURNAL OF NATURAL MEDICINES
发表日期: 2013
DOI: 10.1007/s11418-012-0664-9
卷: 67, 期:1, 页:113-122
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: MEDICINAL-PLANTS ; HERBAL MEDICINES ; CHINESE HERBS ; DNA ; ELECTROPHORESIS ; ARISTOLOLACTAMS ; ARISTOLACTAMS ; NEPHROPATHY ; PRODUCTS
英文摘要:

Aristolochiae Fructus ("Madouling") is derived from the fruits of Aristolochia contorta and A. debilis (Aristolochiaceae). These two species contain potentially nephrotoxic constituents, but are officially used in China. Distinction of constituents and toxicity between these two species remains unclear. A high-performance liquid chromatography method was developed and validated for the simultaneous determination of seven analogues of aristolochic acid (aristolochic acids I, II, IIIa, IVa and VIIa), as well as aristololactams I and II in Aristolochiae Fructus. Chromatographic separation was achieved on a Zorbax SB-C-18 column with a gradient mobile phase comprising acetonitrile and 1 % acetic acid-30 mM triethylamine (20:1, v/v) buffer. Analytes were detected with a diode array detector at 250 and 260 nm. The contents of seven constituents in samples (11 batches of A. contorta fruits, 15 batches of A. debilis fruits and 33 commercial samples of Madouling) were determined. The content of aristolochic acid IVa was higher than that of aristolochic acid VIIa in A. contorta fruits, whereas the opposite was true in A. debilis fruits. This feature can be used to distinguish the two species from each other and identify the resource plant of Madouling. Through a morphological method and a newly found principle based on the ratio AA-IVa/AA-VIIa, we found that the 33 commercial samples collected from 12 provinces in China were all derived from the fruits of A. contorta.

语种: 英语
所属项目编号: 2001BA701A11-07 ; 30873466 ; 2006BAI14B01
项目资助者: State Administration of Traditional Chinese Medicine of the People&prime ; s Republic of China ; National Natural Science Foundation of China ; National Eleventh Five-year Key Technologies R&amp ; D Program of China
WOS记录号: WOS:000312408400014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55032
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Sichuan Univ, W China Pharm, Chengdu 610041, Sichuan, Peoples R China
5.Peking Univ, Sch Pharmaceut Sci, Div Pharmacognosy, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Yu-Qiong,Li, Xiao-Wei,Liu, Guang-Xue,et al. Comparative study of the contents of analogues of aristolochic acid in two kinds of Aristolochiae Fructus by high-performance liquid chromatography[J]. JOURNAL OF NATURAL MEDICINES,2013,67(1):113-122.
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