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学科主题药学
Comparative study of the contents of analogues of aristolochic acid in two kinds of Aristolochiae Fructus by high-performance liquid chromatography
Xu, Yu-Qiong2,3; Li, Xiao-Wei1,2; Liu, Guang-Xue2; Wang, Xuan1; Shang, Ming-Ying2; Li, Xiao-Mei4; Cai, Shao-Qing2,5
关键词Madouling Aristolochia Contorta Aristolochia Debilis Aristolochic Acid Aristololactam
刊名JOURNAL OF NATURAL MEDICINES
2013
DOI10.1007/s11418-012-0664-9
67期:1页:113-122
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]MEDICINAL-PLANTS ; HERBAL MEDICINES ; CHINESE HERBS ; DNA ; ELECTROPHORESIS ; ARISTOLOLACTAMS ; ARISTOLACTAMS ; NEPHROPATHY ; PRODUCTS
英文摘要

Aristolochiae Fructus ("Madouling") is derived from the fruits of Aristolochia contorta and A. debilis (Aristolochiaceae). These two species contain potentially nephrotoxic constituents, but are officially used in China. Distinction of constituents and toxicity between these two species remains unclear. A high-performance liquid chromatography method was developed and validated for the simultaneous determination of seven analogues of aristolochic acid (aristolochic acids I, II, IIIa, IVa and VIIa), as well as aristololactams I and II in Aristolochiae Fructus. Chromatographic separation was achieved on a Zorbax SB-C-18 column with a gradient mobile phase comprising acetonitrile and 1 % acetic acid-30 mM triethylamine (20:1, v/v) buffer. Analytes were detected with a diode array detector at 250 and 260 nm. The contents of seven constituents in samples (11 batches of A. contorta fruits, 15 batches of A. debilis fruits and 33 commercial samples of Madouling) were determined. The content of aristolochic acid IVa was higher than that of aristolochic acid VIIa in A. contorta fruits, whereas the opposite was true in A. debilis fruits. This feature can be used to distinguish the two species from each other and identify the resource plant of Madouling. Through a morphological method and a newly found principle based on the ratio AA-IVa/AA-VIIa, we found that the 33 commercial samples collected from 12 provinces in China were all derived from the fruits of A. contorta.

语种英语
WOS记录号WOS:000312408400014
项目编号2001BA701A11-07 ; 30873466 ; 2006BAI14B01
资助机构State Administration of Traditional Chinese Medicine of the People&prime ; s Republic of China ; National Natural Science Foundation of China ; National Eleventh Five-year Key Technologies R&amp ; D Program of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55032
专题北京大学第三临床医学院_护理部
北京大学药学院_化学生物学系
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Sichuan Univ, W China Pharm, Chengdu 610041, Sichuan, Peoples R China
5.Peking Univ, Sch Pharmaceut Sci, Div Pharmacognosy, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xu, Yu-Qiong,Li, Xiao-Wei,Liu, Guang-Xue,et al. Comparative study of the contents of analogues of aristolochic acid in two kinds of Aristolochiae Fructus by high-performance liquid chromatography[J]. JOURNAL OF NATURAL MEDICINES,2013,67(1):113-122.
APA Xu, Yu-Qiong.,Li, Xiao-Wei.,Liu, Guang-Xue.,Wang, Xuan.,Shang, Ming-Ying.,...&Cai, Shao-Qing.(2013).Comparative study of the contents of analogues of aristolochic acid in two kinds of Aristolochiae Fructus by high-performance liquid chromatography.JOURNAL OF NATURAL MEDICINES,67(1),113-122.
MLA Xu, Yu-Qiong,et al."Comparative study of the contents of analogues of aristolochic acid in two kinds of Aristolochiae Fructus by high-performance liquid chromatography".JOURNAL OF NATURAL MEDICINES 67.1(2013):113-122.
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