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Uralsaponins M-Y, Antiviral Triterpenoid Saponins from the Roots of Glycyrrhiza uralensis
Song, Wei1; Si, Longlong1; Ji, Shuai1; Wang, Han1; Fang, Xiao-mei2; Yu, Li-yan2; Li, Ren-yong3; Liang, Li-na3; Zhou, Demin1; Ye, Min1
刊名JOURNAL OF NATURAL PRODUCTS
2014-07-01
DOI10.1021/np500253m
77期:7页:1632-1643
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]LICORICE ; OLIGOGLYCOSIDES ; CONSTITUENTS ; YUNNANENSIS ; SAPOGENOL ; MEDICINE ; FISCHER ; VIRUS ; CHINA
英文摘要

Thirteen new oleanane-type triterpenoid saponins, uralsaponins M-Y (1-13), and 15 known analogues (14-28) were isolated from the roots of Glycyrrhiza uralensis Fisch. The structures of 1-13 were identified on the basis of extensive NMR and MS data analyses. The sugar residues were identified by gas chromatography and ion chromatography coupled with pulsed amperometric detection after hydrolysis. Saponins containing a galacturonic acid (1-3) or xylose (5) residue are reported from Glycyrrhiza species for the first time. Compounds 1, 7, 8, and 24 exhibited good inhibitory activities against the influenza virus A/WSN/33 (H1N1) in MDCK cells with IC50 values of 48.0, 42.7, 39.6, and 49.1 mu M, respectively, versus 45.6 mu M of the positive control oseltamivir phosphate. In addition, compounds 24 and 28 showed anti-HIV activities with IC50 values of 29.5 and 41.7 mu M, respectively.

语种英语
WOS记录号WOS:000339604300012
项目编号81173644 ; 81222054 ; NCET-11-0019
资助机构National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from China Ministry of Education
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55042
专题北京大学药学院
作者单位1.ThermoFisher Sci Ltd, Beijing 100085, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Song, Wei,Si, Longlong,Ji, Shuai,et al. Uralsaponins M-Y, Antiviral Triterpenoid Saponins from the Roots of Glycyrrhiza uralensis[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(7):1632-1643.
APA Song, Wei.,Si, Longlong.,Ji, Shuai.,Wang, Han.,Fang, Xiao-mei.,...&Ye, Min.(2014).Uralsaponins M-Y, Antiviral Triterpenoid Saponins from the Roots of Glycyrrhiza uralensis.JOURNAL OF NATURAL PRODUCTS,77(7),1632-1643.
MLA Song, Wei,et al."Uralsaponins M-Y, Antiviral Triterpenoid Saponins from the Roots of Glycyrrhiza uralensis".JOURNAL OF NATURAL PRODUCTS 77.7(2014):1632-1643.
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