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Cerebral palsy and multiple births in China
Liu, JM; Li, Z; Lin, Q; Zhao, P; Zhao, FL; Hong, SX; Li, S
关键词Cerebral Palsy Multiple Births Low Birthweight Prevalence Standard Normal Deviate Neonatal Mortality
刊名INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
2000-04-01
29期:2页:292-299
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]TWINS ; PREVALENCE ; TRIPLETS
英文摘要

Background A population-based study on prevalence of cerebral palsy in multiple births has not been carried out in China. The purpose of this paper was to determine the prevalence of cerebral palsy in multiple births and to explore the influence of multiple pregnancy on cerebral palsy after controlling for birthweight.

Methods A cross-sectional study of cerebral palsy was carried out among 388 192 children aged <7 years in seven cities of Jiangsu province in China. Information about birthweight and plurality was obtained from routine health care records. Pediatricians at city level diagnosed all cases. All the doctors involved had taken part in a training programme held by Beijing Medical University. Stratified analysis by birthweight and its standard normal deviate was employed to compare the prevalence of cerebral palsy in multiples and singletons.

Results The prevalence of cerebral palsy for children aged <7 years in multiples was 9.7 per 1000 children (95% confidence interval [CI]: 6.5-14.0), which was 6.5 times that in singletons (95% CI:4.4-9.3). The overall neonatal mortality rate was 60.9 per 1000 liveborn multiples, being highest (944.4 per 1000) in the 500-999 g birthweight groups. Most liveborn multiples weighing <1500 g at birth probably died from diseases related to very low birthweight prior to this study. The prevalence of cerebral palsy in multiple births was likely to be higher than that reported in developed countries for children weighing 1500-2499 g even though our data were from a cross-sectional study. When stratified by birthweight, the prevalence of cerebral Daisy in multiples weighing <2500 g had tended to be lower than that of singletons in the same birthweight group. In contrast, in normal birthweight categories multiple births had a higher prevalence of cerebral palsy than singletons. When stratified by birthweight normal deviate, the prevalence of cerebral palsy in multiple births was uniformly higher than that in singletons in all birthweight strata and the prevalence of cerebral palsy among multiples appeared to be augmented as birthweight increased.

Conclusion The prevalence of cerebral palsy in multiples, 9.7 per 1000 children, is 6.5 times that in singletons. Survival of low birthweight infants is lower in China than in developed countries and survival quality of Chinese children weighing 1500-2499 g needs to be further improved. In terms of birthweight multiples and singletons may be heterogeneous. It might be difficult to directly use actual birthweight specific prevalence to compare the prevalence of cerebral palsy in multiples and singletons. Birthweight normal deviate specific prevalence of cerebral palsy suggests that multiple pregnancy is an independent risk factor for cerebral palsy in all birthweight groups. Multiples are in adverse circumstances very early in gestation and as the foetus matures the risk of cerebral palsy increases.

语种英语
WOS记录号WOS:000087589600015
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55049
专题北京大学第一临床医学院
作者单位1.Beijing Med Univ, Natl Ctr Maternal & Infant Hlth, Beijing 100083, Peoples R China
2.Beijing Med Univ, Affiliated Hosp 1, Beijing 100083, Peoples R China
3.Beijing Med Univ, Affiliated Hosp 3, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liu, JM,Li, Z,Lin, Q,et al. Cerebral palsy and multiple births in China[J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,2000,29(2):292-299.
APA Liu, JM.,Li, Z.,Lin, Q.,Zhao, P.,Zhao, FL.,...&Li, S.(2000).Cerebral palsy and multiple births in China.INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,29(2),292-299.
MLA Liu, JM,et al."Cerebral palsy and multiple births in China".INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 29.2(2000):292-299.
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