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学科主题: 临床医学
题名:
Functional characterization of novel human ARFGAP3
作者: Liu, XQ; Zhang, CG; Xing, GC; Chen, QT; He, HC
关键词: vesicular transport ; ADP ribosylation factor ; GTPase-activating protein ; secreted alkaline phosphatase
刊名: FEBS LETTERS
发表日期: 2001-02-09
卷: 490, 期:1-2, 页:79-83
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: GTPASE-ACTIVATING PROTEIN ; ADP-RIBOSYLATION FACTOR ; SACCHAROMYCES-CEREVISIAE ; GOLGI MEMBRANES ; CHOLERA-TOXIN ; ARF ; HYDROLYSIS ; TRANSPORT ; COMPLEX ; BINDING
英文摘要:

ADP ribosylation factors (ARFs) are critical in the vesicular trafficking pathway. ARF activity is controlled by GTPase-activating proteins (GAPs). We have identified recently a novel tentative ARF GAP derived from human fetal liver, ARFGAP3 (originally named as ARFGAP1). In the present study, we demonstrated that ARFGAP3 had GAP activity in vitro and remarked that the GAP activity of ARFGAP3 was regulated by phospholipids, i.e. phosphatidylinositol 4,5-diphosphate as agonist and phosphatidylcholine as antagonist. ARFGAP3 is a predominantly cytosolic protein, and concentrated in the perinuclear region. Its transient ectopic overexpression in cultured mammalian cells reduced the constitutive secretion of secreted alkaline phosphatase, indicating that ectopic overexpression of ARFGAP3 inhibits the early secretory pathway of proteins in vitro. These results demonstrated that ARFGAP3 is a novel GAP for ARF1 and might be involved in intracellular traffic of proteins and vesicular transport as predicted. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000167007900016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55059
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr Beijing, Beijing Inst Radiat Med, Dept Genom & Proteom, Beijing 100850, Peoples R China
2.Beijing Univ, Teaching Hosp 1, Dept Neurol, Beijing 100034, Peoples R China

Recommended Citation:
Liu, XQ,Zhang, CG,Xing, GC,et al. Functional characterization of novel human ARFGAP3[J]. FEBS LETTERS,2001,490(1-2):79-83.
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