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学科主题临床医学
Functional characterization of novel human ARFGAP3
Liu, XQ; Zhang, CG; Xing, GC; Chen, QT; He, HC
关键词Vesicular Transport Adp Ribosylation Factor Gtpase-activating Protein Secreted Alkaline Phosphatase
刊名FEBS LETTERS
2001-02-09
490期:1-2页:79-83
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]GTPASE-ACTIVATING PROTEIN ; ADP-RIBOSYLATION FACTOR ; SACCHAROMYCES-CEREVISIAE ; GOLGI MEMBRANES ; CHOLERA-TOXIN ; ARF ; HYDROLYSIS ; TRANSPORT ; COMPLEX ; BINDING
英文摘要

ADP ribosylation factors (ARFs) are critical in the vesicular trafficking pathway. ARF activity is controlled by GTPase-activating proteins (GAPs). We have identified recently a novel tentative ARF GAP derived from human fetal liver, ARFGAP3 (originally named as ARFGAP1). In the present study, we demonstrated that ARFGAP3 had GAP activity in vitro and remarked that the GAP activity of ARFGAP3 was regulated by phospholipids, i.e. phosphatidylinositol 4,5-diphosphate as agonist and phosphatidylcholine as antagonist. ARFGAP3 is a predominantly cytosolic protein, and concentrated in the perinuclear region. Its transient ectopic overexpression in cultured mammalian cells reduced the constitutive secretion of secreted alkaline phosphatase, indicating that ectopic overexpression of ARFGAP3 inhibits the early secretory pathway of proteins in vitro. These results demonstrated that ARFGAP3 is a novel GAP for ARF1 and might be involved in intracellular traffic of proteins and vesicular transport as predicted. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000167007900016
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55059
专题北京大学第一临床医学院_神经内科
作者单位1.Chinese Natl Human Genome Ctr Beijing, Beijing Inst Radiat Med, Dept Genom & Proteom, Beijing 100850, Peoples R China
2.Beijing Univ, Teaching Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
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GB/T 7714
Liu, XQ,Zhang, CG,Xing, GC,et al. Functional characterization of novel human ARFGAP3[J]. FEBS LETTERS,2001,490(1-2):79-83.
APA Liu, XQ,Zhang, CG,Xing, GC,Chen, QT,&He, HC.(2001).Functional characterization of novel human ARFGAP3.FEBS LETTERS,490(1-2),79-83.
MLA Liu, XQ,et al."Functional characterization of novel human ARFGAP3".FEBS LETTERS 490.1-2(2001):79-83.
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