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Identification of disease-associated proteins by proteomic approach in ankylosing spondylitis
Liu, Jing; Zhu, Ping; Peng, Jiarou; Li, Keqiu; Du, Jinwei; Gu, Jiangying; Ou, Yuan
关键词Ankylosing Spondylitis Haptoglobin Precursor Serum Proteomic Analysis Epitope Prediction
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2007-06-01
DOI10.1016/j.bbrc.2007.03.179
357期:2页:531-536
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]HLA-B27 TRANSGENIC MICE ; T-CELL EPITOPES ; MASS-SPECTROMETRY ; OVARIAN-CANCER ; HAPTOGLOBIN ; PEPTIDES ; TUMOR ; BIOMARKER ; PREDICTION ; MOLECULES
英文摘要

Ankylosing spondylitis (AS) is a chronic systemic inflammatory disorder of the axial skeleton and shows significant inherited susceptibility. Auto-immune responses have been traditionally considered as a putative pathogenetic event in AS. However, no consistent self-antigen has been identified to responsible for the disorders in AS to this day. In this study, serum protein profiles of AS patients and healthy controls from a large Chinese AS family were investigated by two dimensional electrophoresis analysis. A group of four highly expressed protein spots was observed in all AS patients′ profiles and subsequently identified as isoforms of haptoglobin precursor (pre-Hp) by ESI-Q-TOF MS/MS. Increased expression of haptoglobin precursor were also observed in sera of sporadic AS patients. Moreover, bioinformatics analysis revealed epitopes derived from haptoglobin precursor with high affinity binding to HLA-B*2705, a primary subtype associated with AS. These results indicate that pre-Hp may be involved in the pathogenesis of AS. (c) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000246253700033
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55064
专题北京大学第一临床医学院_血液内科
作者单位1.Peking Univ, Lab Proteom, Beijing, Peoples R China
2.Tianjin Med Univ, Biol Lab, Tianjin, Peoples R China
3.Peking Univ, Hosp 1, Dept Hematol, Ctr Med Genet, Beijing 100034, Peoples R China
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GB/T 7714
Liu, Jing,Zhu, Ping,Peng, Jiarou,et al. Identification of disease-associated proteins by proteomic approach in ankylosing spondylitis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,357(2):531-536.
APA Liu, Jing.,Zhu, Ping.,Peng, Jiarou.,Li, Keqiu.,Du, Jinwei.,...&Ou, Yuan.(2007).Identification of disease-associated proteins by proteomic approach in ankylosing spondylitis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,357(2),531-536.
MLA Liu, Jing,et al."Identification of disease-associated proteins by proteomic approach in ankylosing spondylitis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 357.2(2007):531-536.
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