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学科主题: 临床医学
题名:
Identification of disease-associated proteins by proteomic approach in ankylosing spondylitis
作者: Liu, Jing; Zhu, Ping; Peng, Jiarou; Li, Keqiu; Du, Jinwei; Gu, Jiangying; Ou, Yuan
关键词: ankylosing spondylitis ; haptoglobin precursor ; serum proteomic analysis ; epitope prediction
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2007-06-01
DOI: 10.1016/j.bbrc.2007.03.179
卷: 357, 期:2, 页:531-536
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: HLA-B27 TRANSGENIC MICE ; T-CELL EPITOPES ; MASS-SPECTROMETRY ; OVARIAN-CANCER ; HAPTOGLOBIN ; PEPTIDES ; TUMOR ; BIOMARKER ; PREDICTION ; MOLECULES
英文摘要:

Ankylosing spondylitis (AS) is a chronic systemic inflammatory disorder of the axial skeleton and shows significant inherited susceptibility. Auto-immune responses have been traditionally considered as a putative pathogenetic event in AS. However, no consistent self-antigen has been identified to responsible for the disorders in AS to this day. In this study, serum protein profiles of AS patients and healthy controls from a large Chinese AS family were investigated by two dimensional electrophoresis analysis. A group of four highly expressed protein spots was observed in all AS patients′ profiles and subsequently identified as isoforms of haptoglobin precursor (pre-Hp) by ESI-Q-TOF MS/MS. Increased expression of haptoglobin precursor were also observed in sera of sporadic AS patients. Moreover, bioinformatics analysis revealed epitopes derived from haptoglobin precursor with high affinity binding to HLA-B*2705, a primary subtype associated with AS. These results indicate that pre-Hp may be involved in the pathogenesis of AS. (c) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000246253700033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55064
Appears in Collections:北京大学第一临床医学院_血液内科_期刊论文

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作者单位: 1.Peking Univ, Lab Proteom, Beijing, Peoples R China
2.Tianjin Med Univ, Biol Lab, Tianjin, Peoples R China
3.Peking Univ, Hosp 1, Dept Hematol, Ctr Med Genet, Beijing 100034, Peoples R China

Recommended Citation:
Liu, Jing,Zhu, Ping,Peng, Jiarou,et al. Identification of disease-associated proteins by proteomic approach in ankylosing spondylitis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,357(2):531-536.
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