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Preparation and Evaluation of Poly(Ethylene Glycol)-Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A
Zhang, Yanhui1; Li, Xinru1; Zhou, Yanxia1; Wang, Xiaoning1; Fan, Yating1; Huang, Yanqing2; Liu, Yan1
关键词Monomethoxy Poly(Ethylene Glycol)-Poly(Lactide) Polymeric Micelles Cyclosporine a Solubility Parameter In Vitro Release Intestinal Absorption
刊名NANOSCALE RESEARCH LETTERS
2010-06-01
DOI10.1007/s11671-010-9583-4
5期:6页:917-925
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
资助者National Development of Significant New Drugs ; National Basic Research Program of China ; National Development of Significant New Drugs ; National Basic Research Program of China
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]DRUG-RELEASE BEHAVIORS ; TRIBLOCK COPOLYMER MICELLES ; WATER-SOLUBLE DRUGS ; POLYMERIC MICELLES ; IN-VITRO ; NANOPARTICLES ; CARRIERS ; GLYCOL) ; ABSORPTION ; VIVO
英文摘要

A series of monomethoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) diblock copolymers were designed according to polymer-drug compatibility and synthesized, and mPEG-PLA micelle was fabricated and used as a nanocarrier for solubilization and oral delivery of Cyclosporine A (CyA). CyA was efficiently encapsulated into the micelles with nanoscaled diameter ranged from 60 to 96 nm with a narrow size distribution. The favorable stabilities of CyA-loaded polymeric micelles were observed in simulated gastric and intestinal fluids. The in vitro drug release investigation demonstrated that drug release was retarded by polymeric micelles. The enhanced intestinal absorption of CyA-loaded polymeric micelles, which was comparable to the commercial formulation of CyA (Sandimmun Neoral(A (R))), was found. These suggested that polymeric micelles might be an effective nanocarrier for solubilization of poorly soluble CyA and further improving oral absorption of the drug.

语种英语
所属项目编号2009zx09310-001 ; 2009CB930300
资助者National Development of Significant New Drugs ; National Basic Research Program of China ; National Development of Significant New Drugs ; National Basic Research Program of China
WOS记录号WOS:000278096000002
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55066
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Pharmaceut Teaching Expt Ctr, Beijing 100191, Peoples R China
推荐引用方式
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Zhang, Yanhui,Li, Xinru,Zhou, Yanxia,et al. Preparation and Evaluation of Poly(Ethylene Glycol)-Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A[J]. NANOSCALE RESEARCH LETTERS,2010,5(6):917-925.
APA Zhang, Yanhui.,Li, Xinru.,Zhou, Yanxia.,Wang, Xiaoning.,Fan, Yating.,...&Liu, Yan.(2010).Preparation and Evaluation of Poly(Ethylene Glycol)-Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A.NANOSCALE RESEARCH LETTERS,5(6),917-925.
MLA Zhang, Yanhui,et al."Preparation and Evaluation of Poly(Ethylene Glycol)-Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A".NANOSCALE RESEARCH LETTERS 5.6(2010):917-925.
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