IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Drug Resistance and HCV Coinfection in Former Blood Donors Infected with HIV Type 1 in China
Liu, Jia1; Chen, Xiangmei1; Xie, Qing1; Zhang, Weidong2; Wei, Lai3; Shen, Tao1; Xu, Qiang1; Zhuang, Hui1; Gao, Feng1,4; Lu, Fengmin1
刊名AIDS RESEARCH AND HUMAN RETROVIRUSES
2011-08-01
DOI10.1089/aid.2010.0328
27期:8页:925-930
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Infectious Diseases ; Virology
资助者China National Basic Research 973 Program ; National S & ; T Major Project for Infectious Diseases Control ; China National Basic Research 973 Program ; National S & ; T Major Project for Infectious Diseases Control
研究领域[WOS]Immunology ; Infectious Diseases ; Virology
关键词[WOS]HEPATITIS-C VIRUS ; ANTIRETROVIRAL TREATMENT PROGRAM ; COMMERCIAL PLASMA DONORS ; NATURAL-HISTORY ; EPIDEMIOLOGY ; PREVALENCE ; MUTATION ; THERAPY ; PATIENT
英文摘要

Unhygienic blood collection caused an outbreak of HIV-1 and HCV infections among blood donors in rural areas in Henan province, China. Partial HIV-1 pol and HCV NS5b gene sequences were obtained from 97 persons infected with HIV-1 to determine the efficacy of treatment, the prevalence of drug-resistant mutations, and the impact of HCV infection on disease progression of infection with HIV-1. After antiretroviral therapy, 60 out of 97 HIV-1-infected blood donors had their HIV-1 RNA levels reduced to an undetectable level. Drug-resistant mutations to reverse transcriptase inhibitors were detected in one-third of treatment failure patients, with K103N as the most frequent mutation. Drug-resistant mutations were not detected in the other two-thirds of treatment-failure patients, suggesting a poor adherence to the treatment. The majority of HIV-1-infected patients (91.8%) were also infected with HCV. Sequence analysis showed that they were infected with HCV subtype 1b (47.5%) or 2a (52.5%). HCV viral loads were significantly higher in patients infected with subtype 2a than in patients infected with HCV subtype 1b, although no differences in HIV-1 viral loads and CD4(+)T cell counts was observed between the two subtypes. These results suggest that improved adherence and treatment regimens will be critical to effectively treat HIV-1 and HCV-coinfected patients in resource-limited areas.

语种英语
所属项目编号2005CB523103 ; 2008ZX10002-013
资助者China National Basic Research 973 Program ; National S & ; T Major Project for Infectious Diseases Control ; China National Basic Research 973 Program ; National S & ; T Major Project for Infectious Diseases Control
WOS记录号WOS:000293575900015
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55067
Collection北京大学基础医学院_病原生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Zhengzhou Univ, Dept Epidemiol, Coll Publ Hlth, Zhengzhou, Henan, Peoples R China
3.Peking Univ Peoples Hosp, Inst Hepatol, Beijing, Peoples R China
4.Duke Univ, Med Ctr, Human Vaccine Inst, Durham, NC 27710 USA
Recommended Citation
GB/T 7714
Liu, Jia,Chen, Xiangmei,Xie, Qing,et al. Drug Resistance and HCV Coinfection in Former Blood Donors Infected with HIV Type 1 in China[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES,2011,27(8):925-930.
APA Liu, Jia.,Chen, Xiangmei.,Xie, Qing.,Zhang, Weidong.,Wei, Lai.,...&Lu, Fengmin.(2011).Drug Resistance and HCV Coinfection in Former Blood Donors Infected with HIV Type 1 in China.AIDS RESEARCH AND HUMAN RETROVIRUSES,27(8),925-930.
MLA Liu, Jia,et al."Drug Resistance and HCV Coinfection in Former Blood Donors Infected with HIV Type 1 in China".AIDS RESEARCH AND HUMAN RETROVIRUSES 27.8(2011):925-930.
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