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学科主题: 口腔医学
题名:
Effect of platelet-rich plasma in the treatment of periodontal intrabony defects in humans
作者: Ouyang Xiang-ying; Qiao Jing
关键词: platelet-rich plasma ; periodontal regeneration ; intrabony defect ; bone graft
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2006-09-20
卷: 119, 期:18, 页:1511-1521
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: GUIDED TISSUE REGENERATION ; BOVINE-DERIVED XENOGRAFT ; GROWTH FACTOR-BB ; CELLS IN-VITRO ; HISTOLOGIC EVALUATION ; CLINICAL-TRIAL ; COLLAGEN-SYNTHESIS ; LIGAMENT CELLS ; FACTOR-BETA ; BONE LEVEL
英文摘要:

Background Platelet-rich plasma (PRP) is a kind of natural source of autologous growth factors, and has been used successfully in medical community. However, the effect of PRP in periodontal regeneration is not clear yet. This study was designed to evaluate the effectiveness of PRP as an adjunct to bovine porous bone mineral (BPBM) graft in the treatment of human intrabony defects.

Methods Seventeen intrabony defects in 10 periodontitis patients were randon-fly treated either with PRP and BPBM (test group, n=9) or with BPBM alone (control group, n=8). Clinical parameters were evaluated including changes in probing depth, relative attachment level (measured by Florida Probe and a stent), and bone probing level between baseline and 1 year postoperatively. Standardized periapical radiographs of each defect were taken at baseline, 2 weeks, and 1 year postoperatively, and analyzed by digital subtraction radiography (DSR).

Results Both treatment modalities resulted in significant attachment gain, reduction of probing depth, and bone probing level at 1-year post-surgery compared to baseline. The test group exhibited statistically significant improvement compared to the control sites in probing depth reduction: (4.78 +/- 0.95) mm versus (3.48 +/- 0.41) mm. (P < 0.01); clinical attachment gain: (4.52 +/- 1.14) mm versus (2.85 +/- 0.80) mm (P < 0.01); bone probing reduction: (4.56 +/- 1.04) mm versus (2.88 +/- 0.79) mm (P < 0.01); and defect bone fill: (73.41 +/- 14.78)% versus (47.32 +/- 11.47)% (P < 0.01). DSR analysis of baseline and 1 year postoperatively also showed greater radiographic gains in alveolar bone mass in the test group than in the control group: gray increase (580 +/- 50) grays versus (220 +/- 32) grays (P=0.0001); area with increased gray were (5.21 +/- 1.25) mm(2) versus (3.02 +/- 1.22) mm(2) (P=0.0001).

Conclusions The treatment with a combination of PRP and BPBM led to a significantly favorable clinical improvement in periodontal intrabony defects compared to using BPBM alone. Further studies are necessary to assess the long-term effectiveness of PRP, and a larger sample size is needed.

语种: 英语
WOS记录号: WOS:000240822100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55069
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Ouyang Xiang-ying,Qiao Jing. Effect of platelet-rich plasma in the treatment of periodontal intrabony defects in humans[J]. CHINESE MEDICAL JOURNAL,2006,119(18):1511-1521.
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