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学科主题: 基础医学
题名:
Effect of Panax notoginseng saponins on lipopolysaccharide-induced adhesion of leukocytes in rat mesenteric venules
作者: Sun, K; Wang, CS; Guo, J; Liu, YY; Wang, F; Liu, LY; He, JG; Fan, JY; Han, JY
关键词: Panax notoginseng saponins (PNS) ; leukocyte-endothelium interaction ; leukocyte adhesion molecule ; lipopolysaccharide (LPS)
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2006
卷: 34, 期:1-2, 页:103-108
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: MICROVASCULAR DYSFUNCTION ; REPERFUSION ; ENDOTOXIN ; MICROCIRCULATION ; INJURY ; ACTIVATION ; EXPRESSION ; ISCHEMIA
英文摘要:

Panax notoginseng is the root of the Chinese traditional herb, Panax notoginseng (Burk) F. H. Chen. This study was aimed to investigate the inhibitory effect of Panax notoginseng saponins (PNS) on the leukocyte adhesion and the expression of adhesion molecules in rat mesentery venules. Male Sprague-Dawley rats were anesthetized with urethane. These were divided into control, LPS (perfused with lipopolysaccharide), and PNS group (perfused with PNS). The mesenteric microcirculation was observed under a videomicroscope. The number of adherent leukocytes, which attached to the vascular wall during more than 10 seconds, was counted along single venules (30-50 mu m in diameter, 200 mu m in length). The expression of adhesion molecules was examined using flow-cytometry in blood which was taken from the abdominal aorta and incubated with FITC-labeled CD11b (or CD18) antibodies. The results showed that different changes in the leukocyte adhesion and the expression of adhesion molecules among three groups. In LPS group, the leukocyte adhesion increased significantly after 20 minutes during the observation time, while it was reduced markedly in PNS group. The expression of CD11b and CD18 on the neutrophils was induced in LPS group, while it was reduced significantly in PNS group. It was suggested that PNS could reduce leukocyte adhesion in venules under the inhibitory effect on the expression of adhesion molecules (CD11b and CD18) on neutrophils.

语种: 英语
WOS记录号: WOS:000236802600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55070
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China
2.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Integrated Tradit Chinese & Western Med, Beijing 100083, Peoples R China

Recommended Citation:
Sun, K,Wang, CS,Guo, J,et al. Effect of Panax notoginseng saponins on lipopolysaccharide-induced adhesion of leukocytes in rat mesenteric venules[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2006,34(1-2):103-108.
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