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学科主题: 临床医学
题名:
Clinical 3.0 T Magnetic Resonance Scanner to Be Used for Imaging of Mouse Atherosclerotic Lesions
作者: Li, Xubin1,2,3; Gu, Huidong1,2; Feng, Hongqing1,2; Du, Xiangke3; Qiu, Bensheng1,2; Yang, Xiaoming1,2
刊名: APPLIED MAGNETIC RESONANCE
发表日期: 2010-12-01
DOI: 10.1007/s00723-010-0174-4
卷: 39, 期:4, 页:401-407
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Physics, Atomic, Molecular & Chemical ; Spectroscopy
研究领域[WOS]: Physics ; Spectroscopy
关键词[WOS]: BLOOD MR-ANGIOGRAPHY ; IN-VIVO ; APOLIPOPROTEIN-E ; AORTIC-ARCH ; SPIN-ECHO ; MICE ; HYPERCHOLESTEROLEMIA ; PROGRESSION
英文摘要:

Magnetic resonance imaging (MRI) is a useful tool for non-invasive identification and characterization of atherosclerotic plaques in both basic science and clinical practice. To date, the reported studies on in vivo vascular MRI of small animals, such as mice and rats, are mainly performed on high-field micro-MR scanners, which are not always available in many academic institutions and basic research units. This study aimed to explore the possibility of generating high-resolution MR images of the atherosclerotic aortic walls/plaques of mice using a clinical 3.0 T MR scanner with a dedicated solenoid mouse coil. An atherosclerotic mouse model was first generated by feeding 8 ApoE(-)/(-) mice an atherogenic diet. MR images of the ascending aortas of these mice were then achieved using a three-dimensional black-blood turbo spin-echo sequence (repetition time TR = 4 heart echo time TE = 10 ms). The MRI displayed a clear view of the aortic lumens and the atherosclerotic lesions, which correlated significantly well with subsequent histological confirmations (linear regression analysis, r = 0.73, P = 0.04). This study demonstrated that a clinical 3.0 T MR scanner can be used for high-resolution imaging of mouse atherosclerotic lesions to some extent.

语种: 英语
所属项目编号: R01 HL078672
项目资助者: NIH ; China Scholarship Council
WOS记录号: WOS:000284154600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55072
Appears in Collections:北京大学第二临床医学院_放射科_期刊论文

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作者单位: 1.Univ Washington, Sch Med, Image Guided Biomol Intervent Sect, Dept Radiol, Seattle, WA 98105 USA
2.Univ Washington, Sch Med, Inst Stem Cell & Regenerat Med, Seattle, WA 98105 USA
3.Peking Univ, Peoples Hosp, Dept Radiol, Beijing 100044, Peoples R China

Recommended Citation:
Li, Xubin,Gu, Huidong,Feng, Hongqing,et al. Clinical 3.0 T Magnetic Resonance Scanner to Be Used for Imaging of Mouse Atherosclerotic Lesions[J]. APPLIED MAGNETIC RESONANCE,2010,39(4):401-407.
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