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学科主题临床医学
Clinical 3.0 T Magnetic Resonance Scanner to Be Used for Imaging of Mouse Atherosclerotic Lesions
Li, Xubin1,2,3; Gu, Huidong1,2; Feng, Hongqing1,2; Du, Xiangke3; Qiu, Bensheng1,2; Yang, Xiaoming1,2
刊名APPLIED MAGNETIC RESONANCE
2010-12-01
DOI10.1007/s00723-010-0174-4
39期:4页:401-407
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Physics, Atomic, Molecular & Chemical ; Spectroscopy
资助者NIH ; China Scholarship Council ; NIH ; China Scholarship Council
研究领域[WOS]Physics ; Spectroscopy
关键词[WOS]BLOOD MR-ANGIOGRAPHY ; IN-VIVO ; APOLIPOPROTEIN-E ; AORTIC-ARCH ; SPIN-ECHO ; MICE ; HYPERCHOLESTEROLEMIA ; PROGRESSION
英文摘要

Magnetic resonance imaging (MRI) is a useful tool for non-invasive identification and characterization of atherosclerotic plaques in both basic science and clinical practice. To date, the reported studies on in vivo vascular MRI of small animals, such as mice and rats, are mainly performed on high-field micro-MR scanners, which are not always available in many academic institutions and basic research units. This study aimed to explore the possibility of generating high-resolution MR images of the atherosclerotic aortic walls/plaques of mice using a clinical 3.0 T MR scanner with a dedicated solenoid mouse coil. An atherosclerotic mouse model was first generated by feeding 8 ApoE(-)/(-) mice an atherogenic diet. MR images of the ascending aortas of these mice were then achieved using a three-dimensional black-blood turbo spin-echo sequence (repetition time TR = 4 heart echo time TE = 10 ms). The MRI displayed a clear view of the aortic lumens and the atherosclerotic lesions, which correlated significantly well with subsequent histological confirmations (linear regression analysis, r = 0.73, P = 0.04). This study demonstrated that a clinical 3.0 T MR scanner can be used for high-resolution imaging of mouse atherosclerotic lesions to some extent.

语种英语
所属项目编号R01 HL078672
资助者NIH ; China Scholarship Council ; NIH ; China Scholarship Council
WOS记录号WOS:000284154600008
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文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55072
专题北京大学第二临床医学院_放射科
作者单位1.Univ Washington, Sch Med, Image Guided Biomol Intervent Sect, Dept Radiol, Seattle, WA 98105 USA
2.Univ Washington, Sch Med, Inst Stem Cell & Regenerat Med, Seattle, WA 98105 USA
3.Peking Univ, Peoples Hosp, Dept Radiol, Beijing 100044, Peoples R China
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Li, Xubin,Gu, Huidong,Feng, Hongqing,et al. Clinical 3.0 T Magnetic Resonance Scanner to Be Used for Imaging of Mouse Atherosclerotic Lesions[J]. APPLIED MAGNETIC RESONANCE,2010,39(4):401-407.
APA Li, Xubin,Gu, Huidong,Feng, Hongqing,Du, Xiangke,Qiu, Bensheng,&Yang, Xiaoming.(2010).Clinical 3.0 T Magnetic Resonance Scanner to Be Used for Imaging of Mouse Atherosclerotic Lesions.APPLIED MAGNETIC RESONANCE,39(4),401-407.
MLA Li, Xubin,et al."Clinical 3.0 T Magnetic Resonance Scanner to Be Used for Imaging of Mouse Atherosclerotic Lesions".APPLIED MAGNETIC RESONANCE 39.4(2010):401-407.
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