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作者:
学科主题: 基础医学
题名:
Molecular Insights of c-Myc in Cellular Senescence
Cheng Qian; Yuan Fu-Wen; Tong Tan-Jun
关键词: c-Myc ; cellular senescence ; CDK2 ; WRN
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2014-03-01
DOI: 10.3724/SP.J.1206.2013.00313
卷: 41, 期:3, 页:266-272
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: WERNER-SYNDROME PROTEIN ; AVIAN MYELOCYTOMATOSIS VIRUS ; ONCOGENE-INDUCED SENESCENCE ; REPLICATION FORK ; DNA HELICASE ; CELLS ; GENE ; WRN ; TELOMERASE ; TARGET
英文摘要:

Cellular senescence is a terminal growth arrest in the G1 phase of the cell cycle, featuring characteristic morphological, biochemical, and epigenetical changes. Cellular senescence results from telomere erosion, DNA damage, hypoxia, or oncogene deregulation, and it is one of main barriers of tumorigenesis. Proto-oncogene c-Myc encodes a transcription factor that can regulate the transcription of many genes, thereby affects different biological processes such as the cell cycle progression, senescence, apoptosis, metabolism, and so on. The c-Myc protein is closely related to cellular senescence, and it has abilities to affect cellular senescence-associated genes (hTERT, p16, p53, Bmi-1 and p27) transcription. The activation of c-Myc not only inhibits replicative senescence, but also can inhibit oncogene-induced senescence. The c-Myc suppresses Ras-induced cellular senescence with help with CDK2. The inactivation of c-Myc induces senescence in untransformed cells(such as human fibroblasts) as well as in many tumor cells. However, similar to ras gene, under certain conditions, c-Myc can induce cell senescence, and contributes to WRN gene-deficient cells senescence.

语种: 中文
所属项目编号: 2013CB530801 ; 2012CB911293 ; 81372164
项目资助者: National Basic Research Programs of China ; National Natural Science Foundation of China
WOS记录号: WOS:000333482000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55073
Appears in Collections:基础医学院_北京大学衰老研究中心_期刊论文

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作者单位: Peking Univ, Res Ctr Aging, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China

Recommended Citation:
Cheng Qian,Yuan Fu-Wen,Tong Tan-Jun. Molecular Insights of c-Myc in Cellular Senescence[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2014,41(3):266-272.
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