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学科主题临床医学
RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells
Yan, T.; Tang, G.; Ren, T.; Shen, D.; Sun, K.; Liang, W.; Guo, W.
关键词Cops3 Osteogenic Sarcoma Metastasis Immunostaining Sirna
刊名CANCER GENE THERAPY
2011-06-01
DOI10.1038/cgt.2011.16
18期:6页:450-456
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]HIGH-GRADE OSTEOSARCOMA ; STUDY-GROUP PROTOCOLS ; PROGNOSTIC-FACTORS ; CANCER METASTASIS ; POOR SURVIVAL ; AMPLIFICATION ; EXPRESSION ; CHEMOTHERAPY ; 17P11.2-SIMILAR-TO-P12 ; OVEREXPRESSION
英文摘要

Metastatic disease is the primary cause of mortality among patients with osteogenic sarcoma (OGS). In this study, we aimed to identify the relationship of COPS3 gene expression to metastasis. Immunohistochemical staining for COPS3 was performed on 65 OGS samples (37 without and 28 with metastatic disease); 18.9% (7/37) of specimens from patients with no metastasis and 57.1% (16/28) of specimens from patients with metastasis showed intense staining of COPS3. Comparison of COPS3 expression between a poorly metastatic osteosarcoma cell line (SAOS-2) and highly metastatic osteosarcoma cell line (HOS) showed stronger expression of COPS3 in HOS cells. Inhibiting COPS3 function by siRNA resulted in reduced proliferation and migration of HOS cells. Inhibition of COPS3 gene downregulated expression of the MAPK signaling pathway, which has an important role in metastasis of OGS. Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. Cancer Gene Therapy (2011) 18, 450-456; doi:10.1038/cgt.2011.16; published online 25 March 2011

语种英语
WOS记录号WOS:000290713500008
项目编号30600621
资助机构National Natural Science Foundation of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55074
专题北京大学第二临床医学院_骨肿瘤科
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学第一临床医学院_介入血管外科
北京大学公共卫生学院_学院办公室
作者单位Peking Univ Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100044, Peoples R China
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Yan, T.,Tang, G.,Ren, T.,et al. RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells[J]. CANCER GENE THERAPY,2011,18(6):450-456.
APA Yan, T..,Tang, G..,Ren, T..,Shen, D..,Sun, K..,...&Guo, W..(2011).RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells.CANCER GENE THERAPY,18(6),450-456.
MLA Yan, T.,et al."RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells".CANCER GENE THERAPY 18.6(2011):450-456.
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