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学科主题: 临床医学
题名:
RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells
作者: Yan, T.; Tang, G.; Ren, T.; Shen, D.; Sun, K.; Liang, W.; Guo, W.
关键词: COPS3 ; osteogenic sarcoma ; metastasis ; immunostaining ; siRNA
刊名: CANCER GENE THERAPY
发表日期: 2011-06-01
DOI: 10.1038/cgt.2011.16
卷: 18, 期:6, 页:450-456
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]: HIGH-GRADE OSTEOSARCOMA ; STUDY-GROUP PROTOCOLS ; PROGNOSTIC-FACTORS ; CANCER METASTASIS ; POOR SURVIVAL ; AMPLIFICATION ; EXPRESSION ; CHEMOTHERAPY ; 17P11.2-SIMILAR-TO-P12 ; OVEREXPRESSION
英文摘要:

Metastatic disease is the primary cause of mortality among patients with osteogenic sarcoma (OGS). In this study, we aimed to identify the relationship of COPS3 gene expression to metastasis. Immunohistochemical staining for COPS3 was performed on 65 OGS samples (37 without and 28 with metastatic disease); 18.9% (7/37) of specimens from patients with no metastasis and 57.1% (16/28) of specimens from patients with metastasis showed intense staining of COPS3. Comparison of COPS3 expression between a poorly metastatic osteosarcoma cell line (SAOS-2) and highly metastatic osteosarcoma cell line (HOS) showed stronger expression of COPS3 in HOS cells. Inhibiting COPS3 function by siRNA resulted in reduced proliferation and migration of HOS cells. Inhibition of COPS3 gene downregulated expression of the MAPK signaling pathway, which has an important role in metastasis of OGS. Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. Cancer Gene Therapy (2011) 18, 450-456; doi:10.1038/cgt.2011.16; published online 25 March 2011

语种: 英语
所属项目编号: 30600621
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000290713500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55074
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

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作者单位: Peking Univ Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Yan, T.,Tang, G.,Ren, T.,et al. RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells[J]. CANCER GENE THERAPY,2011,18(6):450-456.
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