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学科主题: 临床医学
题名:
A morphologic study of retinal toxicity induced by triamcinolone acetonide vehicles in rabbit eyes
作者: Li, Qian1; Wang, Jingzhao1; Yang, Lin1; Mo, Bin1; Zeng, Huiyang2; Wang, Ningli1; Liu, Wu1
关键词: triamcinolone acetonide vehicle ; retinal toxicity ; intravitreal injection ; rabbit
刊名: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
发表日期: 2008-03-01
卷: 28, 期:3, 页:504-510
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: CYSTOID MACULAR EDEMA ; PIGMENT EPITHELIAL-CELLS ; INTRAVITREAL TRIAMCINOLONE ; CRYSTALLINE CORTISONE ; ADJUNCTIVE TREATMENT ; INTRAOCULAR INJECTION ; BENZYL ALCOHOL ; PSEUDOHYPOPYON ; ENDOPHTHALMITIS ; PURIFICATION
英文摘要:

Purpose: To evaluate the toxic effects of two triamcinolone acetonide (TA) vehicles on rabbit retina at different volumes.

Methods: Vehicle A and B were prepared from two TA injections by centrifugation. Thirty-six New Zealand white rabbits were intravitreally injected with vehicle A, B, or balanced saline solution at 0.1 mL or 0.2 mL respectively. The eyes were examined by indirect ophthalmoscope, light microscope, and transmission electron microscope up to week 8 postinjection.

Results: Eyes with vehicle A appeared normal under the ophthalmoscope, but showed disorganization in retinal inner nuclear layer and photoreceptor layer in pathologic analyses. Eyes with vehicle B displayed more significant retinal changes including retinal hemorrhage, vascular narrowing, myelinated fiber edema, retinal necrosis and atrophy, and photoreceptor apoptosis. There was an increase in degree of the above damages as the volume of either vehicle increased.

Conclusion: Both vehicle A and B caused volume-related toxicity in rabbit retina. The intensity of the toxic effects of different vehicles may differ. Reducing or decanting the vehicles should be considered before intravitreal use of TA injections.

语种: 英语
WOS记录号: WOS:000253951500017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55075
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing 100730, Peoples R China
2.Peking Univ, Ctr Eye, Peking Univ Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Li, Qian,Wang, Jingzhao,Yang, Lin,et al. A morphologic study of retinal toxicity induced by triamcinolone acetonide vehicles in rabbit eyes[J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,2008,28(3):504-510.
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