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High-Dose Cyclophosphamide Therapy Associated with Diffuse Alveolar Hemorrhage after Allogeneic Hematopoietic Stem Cell Transplantation
Mo, Xiao-Dong; Xu, Lan-Ping; Liu, Dai-Hong; Zhang, Xiao-Hui; Chen, Huan; Chen, Yu-Hong; Han, Wei; Wang, Yu; Wang, Feng-Rong; Wang, Jing-Zhi; Liu, Kai-Yan; Huang, Xiao-Jun1,2
关键词Diffuse Alveolar Hemorrhage Transplantation Cyclophosphamide Corticosteroid
刊名RESPIRATION
2013
DOI10.1159/000345592
86期:6页:453-461
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Respiratory System
研究领域[WOS]Respiratory System
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; LUNG-DISEASE ; RECIPIENTS ; DIAGNOSIS ; CORTICOSTEROIDS ; MICROANGIOPATHY ; COMPLICATIONS
英文摘要

Background: The occurrence of diffuse alveolar hemorrhage (DAH) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare but severe. There are few reports that have examined the correlation between pre-HSCT chemotherapeutic exposure and DAH. Objectives: We examine the role of pre-HSCT chemotherapeutic exposure, conditioning regimens, pre-HSCT comorbidities and transplant-related complications in the development of DAH after allo-HSCT and evaluate the effect of the high-dose corticosteroid strategy on DAH. Methods: A retrospective nested case-control study was designed. Cases with DAH and controls matched for year of allo-HSCT and length of follow-up were identified from a cohort of 597 patients who underwent allo-HSCT between 2006 and 2011 for acute leukemia. Results: Twenty-two patients suffered from DAH; the mean age at the time of presentation was 30.4 years (+/- 12.9) and the mean time to presentation was 7.8 months (+/- 8.1) post-HSCT. The pre-HSCT cyclophosphamide exposure and the cumulative cyclophosphamide dose were significantly higher among the DAH cases compared with the controls, and the cumulative cyclophosphamide dose of >= 5 g/m(2) was independently associated with DAH (OR = 3.4, p = 0.030). High-dose corticosteroid treatment did not significantly improve survival. Conclusions: From these results we can identify patients who are at a higher risk of developing DAH after allo-HSCT, and we found that high-dose corticosteroid therapy may not alter the poor outcome associated with this syndrome. Copyright (C) 2012 S. Karger AG, Basel

语种英语
WOS记录号WOS:000329924300002
项目编号2011AA020105 ; 30971292
资助机构National High Technology Research and Development Program of China (Program 863) ; National Natural Science Foundation of China ; American Journal Experts
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55078
专题北京大学第二临床医学院
北京大学第二临床医学院_血液科
作者单位1.Inst Hematol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Beijing Key Lab Hematopoit Stem Cell Transplantat, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Mo, Xiao-Dong,Xu, Lan-Ping,Liu, Dai-Hong,et al. High-Dose Cyclophosphamide Therapy Associated with Diffuse Alveolar Hemorrhage after Allogeneic Hematopoietic Stem Cell Transplantation[J]. RESPIRATION,2013,86(6):453-461.
APA Mo, Xiao-Dong.,Xu, Lan-Ping.,Liu, Dai-Hong.,Zhang, Xiao-Hui.,Chen, Huan.,...&Huang, Xiao-Jun.(2013).High-Dose Cyclophosphamide Therapy Associated with Diffuse Alveolar Hemorrhage after Allogeneic Hematopoietic Stem Cell Transplantation.RESPIRATION,86(6),453-461.
MLA Mo, Xiao-Dong,et al."High-Dose Cyclophosphamide Therapy Associated with Diffuse Alveolar Hemorrhage after Allogeneic Hematopoietic Stem Cell Transplantation".RESPIRATION 86.6(2013):453-461.
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