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Depression and alterations in hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axis function in male abstinent methamphetamine abusers
Li, Su-Xia1; Yan, Shi-Yan1; Bao, Yan-Ping1; Lian, Zhi1; Qu, Zhi1; Wu, Ya-Ping1,2; Liu, Zhi-Min1
关键词Methamphetamine Abuse Depression Triiodothyronine Thyroxine Thyroid-stimulating Hormone Adrenocorticotropic Hormone Cortisol
刊名HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
2013-09-01
DOI10.1002/hup.2335
28期:5页:477-483
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Social Sciences
类目[WOS]Clinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
关键词[WOS]DOPAMINE TRANSPORTER DENSITY ; CORTICOTROPIN-RELEASING-FACTOR ; POSITRON-EMISSION-TOMOGRAPHY ; NERVE-TERMINAL DEGENERATION ; PSYCHIATRIC-SYMPTOMS ; INDUCED NEUROTOXICITY ; MAJOR DEPRESSION ; COGNITIVE PERFORMANCE ; PSYCHOLOGICAL STRESS ; NEURONAL APOPTOSIS
英文摘要

The present study was to investigate depression and alterations in the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-thyroid (HPT) axis function in methamphetamine (METH) abusers after abstinence. Depression was assessed using the 13-item Beck Depression Inventory (BDI-13) scale; blood samples from in-patients who were METH abusers and age-matched and sex-matched healthy controls were collected. The demographic characteristics and history of METH abuse also was assessed. We found that serum levels of adrenocorticotropic hormone (ACTH) and thyroxine were increased; and serum levels of cortisol, triiodothyronine, and thyroid-stimulating hormone were decreased; and the BDI score was higher in METH abusers compared with control. In addition, there was no correlation between the BDI-13 score and any of hormones of HPA and HPT axis was found. Particularly, we found abnormally higher ACTH level and mismatched with lower cortisol level in abstinent METH abusers. These results indicate that METH abusers and that their HPA and HPT functions are all altered after abstinence. Chronically using METH may destroy the regulatory function of the HPA axis, especially the feedback regulation of cortisol to ACTH. Copyright (c) 2013 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000324047000010
项目编号20090001120132 ; 2009CB522007
资助机构Department of Education of China ; National Basic Research Project
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55080
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Weinan Vocat & Tech Coll, Weinan 714000, Shanxi Province, Peoples R China
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GB/T 7714
Li, Su-Xia,Yan, Shi-Yan,Bao, Yan-Ping,et al. Depression and alterations in hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axis function in male abstinent methamphetamine abusers[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2013,28(5):477-483.
APA Li, Su-Xia.,Yan, Shi-Yan.,Bao, Yan-Ping.,Lian, Zhi.,Qu, Zhi.,...&Liu, Zhi-Min.(2013).Depression and alterations in hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axis function in male abstinent methamphetamine abusers.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,28(5),477-483.
MLA Li, Su-Xia,et al."Depression and alterations in hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axis function in male abstinent methamphetamine abusers".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 28.5(2013):477-483.
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