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学科主题: 药物依赖
题名:
Depression and alterations in hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axis function in male abstinent methamphetamine abusers
作者: Li, Su-Xia1; Yan, Shi-Yan1; Bao, Yan-Ping1; Lian, Zhi1; Qu, Zhi1; Wu, Ya-Ping1,2; Liu, Zhi-Min1
关键词: methamphetamine abuse ; depression ; triiodothyronine ; thyroxine ; thyroid-stimulating hormone ; adrenocorticotropic hormone ; cortisol
刊名: HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
发表日期: 2013-09-01
DOI: 10.1002/hup.2335
卷: 28, 期:5, 页:477-483
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Social Sciences
类目[WOS]: Clinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
关键词[WOS]: DOPAMINE TRANSPORTER DENSITY ; CORTICOTROPIN-RELEASING-FACTOR ; POSITRON-EMISSION-TOMOGRAPHY ; NERVE-TERMINAL DEGENERATION ; PSYCHIATRIC-SYMPTOMS ; INDUCED NEUROTOXICITY ; MAJOR DEPRESSION ; COGNITIVE PERFORMANCE ; PSYCHOLOGICAL STRESS ; NEURONAL APOPTOSIS
英文摘要:

The present study was to investigate depression and alterations in the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-thyroid (HPT) axis function in methamphetamine (METH) abusers after abstinence. Depression was assessed using the 13-item Beck Depression Inventory (BDI-13) scale; blood samples from in-patients who were METH abusers and age-matched and sex-matched healthy controls were collected. The demographic characteristics and history of METH abuse also was assessed. We found that serum levels of adrenocorticotropic hormone (ACTH) and thyroxine were increased; and serum levels of cortisol, triiodothyronine, and thyroid-stimulating hormone were decreased; and the BDI score was higher in METH abusers compared with control. In addition, there was no correlation between the BDI-13 score and any of hormones of HPA and HPT axis was found. Particularly, we found abnormally higher ACTH level and mismatched with lower cortisol level in abstinent METH abusers. These results indicate that METH abusers and that their HPA and HPT functions are all altered after abstinence. Chronically using METH may destroy the regulatory function of the HPA axis, especially the feedback regulation of cortisol to ACTH. Copyright (c) 2013 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 20090001120132 ; 2009CB522007
项目资助者: Department of Education of China ; National Basic Research Project
WOS记录号: WOS:000324047000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55080
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Weinan Vocat & Tech Coll, Weinan 714000, Shanxi Province, Peoples R China

Recommended Citation:
Li, Su-Xia,Yan, Shi-Yan,Bao, Yan-Ping,et al. Depression and alterations in hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axis function in male abstinent methamphetamine abusers[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2013,28(5):477-483.
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