学科主题基础医学
The Egf Receptor-Sox2-Egf Receptor Feedback Loop Positively Regulates the Self-Renewal of Neural Precursor Cells
Hu, Qikuan2,3; Zhang, Lirong2; Wen, Jinhua1,2; Wang, Shuling2; Li, Meiyu2; Feng, Ruopeng2; Yang, Xiaolong2; Li, Lingsong2
关键词Neural procursor cells Egfr Sox2 Self-renewal
刊名STEM CELLS
2010-02-01
DOI10.1002/stem.246
28期:2页:279-286
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Oncology ; Cell Biology ; Hematology
研究领域[WOS]Cell Biology ; Biotechnology & Applied Microbiology ; Oncology ; Hematology
关键词[WOS]EPIDERMAL-GROWTH-FACTOR ; SEX-DETERMINING REGION ; CENTRAL-NERVOUS-SYSTEM ; STEM-CELLS ; SUBVENTRICULAR ZONE ; PROGENITOR CELLS ; VASCULAR NICHE ; ASTROCYTES ; FOREBRAIN ; BRAIN
英文摘要

The transcriptional factor Sox2 and epidermal growth factor receptor (Egfr)-mediated signaling are both required for self-renewal of neural precursor cells (NPCs). However, the mechanism by which these factors coordinately regulate this process is largely unknown. Here we show that Egfr-mediated signaling promotes Sox2 expression, which in turn binds to the Egfr promoter and directly upregulates Egfr expression. Knockdown of Sox2 by RNA interference downregulates Egfr expression and attenuates colony formation of NPCs, whereas overexpression of Sox2 elevates Egfr expression and promotes NPC self-renewal. Moreover, the effect of Sox2 on NPC self-renewal is completely inhibited by AG1478, a specific inhibitor for Egfr; it is also inhibited by LY294002 and U0126, selective antagonists for phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated kinase (Erk1/2), respectively. Collectively, we conclude that NPC self-renewal is enhanced through a novel cellular feedback loop with mutual regulation of Egfr and Sox2. STEM CELLS 2010;28:279-286

语种英语
WOS记录号WOS:000275058400012
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被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55081
专题北京大学基础医学院_北京大学干细胞研究中心
北京大学基础医学院
作者单位1.Peking Univ, Stem Cell Res Ctr, Dept Cell Biol, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Natl Ctr Int Res, Beijing 100191, Peoples R China
3.Ningxia Med Sch, Ningxia, Peoples R China
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GB/T 7714
Hu, Qikuan,Zhang, Lirong,Wen, Jinhua,et al. The Egf Receptor-Sox2-Egf Receptor Feedback Loop Positively Regulates the Self-Renewal of Neural Precursor Cells[J]. STEM CELLS,2010,28(2):279-286.
APA Hu, Qikuan.,Zhang, Lirong.,Wen, Jinhua.,Wang, Shuling.,Li, Meiyu.,...&Li, Lingsong.(2010).The Egf Receptor-Sox2-Egf Receptor Feedback Loop Positively Regulates the Self-Renewal of Neural Precursor Cells.STEM CELLS,28(2),279-286.
MLA Hu, Qikuan,et al."The Egf Receptor-Sox2-Egf Receptor Feedback Loop Positively Regulates the Self-Renewal of Neural Precursor Cells".STEM CELLS 28.2(2010):279-286.
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