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Hypermethylation of the p15(INK4B) gene in acute leukemia and myelodysplastic syndromes
Chen, H; Wu, SL
关键词Suppressor Gene P15(Ink4b) Dna Methylation Acute Leukemia Myelodysplastic Syndromes
刊名CHINESE MEDICAL JOURNAL
2002-07-01
115期:7页:987-990
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]ACUTE MYELOID-LEUKEMIA ; METHYLATION
英文摘要

Objective To detect the methylation pattern of the p15(INK4B) gene and to explore its significance in the pathogenesis of acute leukemia (AL) and leukemic transformation of myelodysplastic syndromes (MDS).

Methods A total of 49 AL cases and 22 MDS cases were analyzed by methylation specific polymerase chain reaction (MSP) for methylation patterns in CpG islands of the p15(INK4B) gene.

Results Hypermethylation of the p15(INK4B) gene was found in 90% (26/29) of newly diagnosed AL, including 46% with complete methylation and 54% with partial methylation. All 3 evolved AL from MDS and 9 relapsed AL showed a methylated p15(INK4B) gene and the proportion of complete methylation was 67% and 56% respectively. Only 5 of 11 (45%) AL in remission, including 2 in complete remission (CR) and 3 in partial remission ( PR), were partially methylated. The frequency of p15(INK4B) gene methylation in newly diagnosed or relapsed AL was significantly higher than that in AL in the remission stage ( P = 0. 002). P15(INK4B) gene methylation was found in 5 of 13 (38%) low-risk MDS (RA/RAS) patients and 80% of them showed only partial methylation. However, p15(INK4B) gene methylation was found in all 9 cases in the highrisk group (RAEB/RAEB-T), including complete methylation in 56%, significantly different from the low-risk IVIDS group ( P = 0.002).

Conclusions Hypermethylation of the p15(INK4B) gene occurs frequently in leukemia and high-risk IVIDS. It is possible that hypermethylation of this gene is related to the pathogenesis and development of AL and IVIDS. It may be used as a gene marker to detect minimal residual disease, relapse of AL and leukemic transformation in MDS.

语种英语
WOS记录号WOS:000177175200006
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55083
专题北京大学第一临床医学院_血液内科
作者单位Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China
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GB/T 7714
Chen, H,Wu, SL. Hypermethylation of the p15(INK4B) gene in acute leukemia and myelodysplastic syndromes[J]. CHINESE MEDICAL JOURNAL,2002,115(7):987-990.
APA Chen, H,&Wu, SL.(2002).Hypermethylation of the p15(INK4B) gene in acute leukemia and myelodysplastic syndromes.CHINESE MEDICAL JOURNAL,115(7),987-990.
MLA Chen, H,et al."Hypermethylation of the p15(INK4B) gene in acute leukemia and myelodysplastic syndromes".CHINESE MEDICAL JOURNAL 115.7(2002):987-990.
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