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学科主题临床医学
Plasma prolactin level and risk of incident hypertension in postmenopausal women
Zhang, Luxia1,2,3,4; Curhan, Gary C.1,2,3; Forman, John P.1,2,3
关键词Epidemiology Human Hypertension Prolactin Risk Factor
刊名JOURNAL OF HYPERTENSION
2010-07-01
DOI10.1097/HJH.0b013e328339f254
28期:7页:1400-1405
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ARTERIAL BLOOD-PRESSURE ; RENAL-FUNCTION ; BREAST-CANCER ; HYPERPROLACTINEMIA ; PREMENOPAUSAL ; QUESTIONNAIRE ; INFLAMMATION ; PREGNANCY ; ESTROGEN ; ADHESION
英文摘要

Background Laboratory and cross-sectional human studies suggest a potential role for prolactin in the pathogenesis of hypertension; however, the prospective association between prolactin and hypertension has not been previously reported.

Methods We prospectively examined the association between daytime plasma prolactin levels and the risk of incident hypertension among 874 postmenopausal women who were participants of the Nurses′ Health Study. Cox proportional hazards regression models were used to adjust for potential confounders.

Results We identified 183 incident cases of hypertension during 8 years of follow-up. After adjusting for potential confounders, the relative risk of hypertension for a 1-standard deviation higher plasma prolactin was 1.31 (95% confidence interval 1.05-1.62). Compared with women with plasma prolactin levels of 8.0 ng/ml or below, the multivariable relative risk of incident hypertension for those with prolactin levels above 8.0 ng/ml was 1.34 (95% confidence interval 0.90-1.99).

Conclusion A higher daytime plasma prolactin level is independently associated with an increased risk of incident hypertension among postmenopausal women. J Hypertens 28: 1400-1405 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000279579800011
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55085
专题北京大学第一临床医学院_肾脏内科
作者单位1.Harvard Univ, Sch Med, Boston, MA USA
2.Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA
3.Brigham & Womens Hosp, Dept Med, Div Renal, Boston, MA 02115 USA
4.Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing 100871, Peoples R China
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GB/T 7714
Zhang, Luxia,Curhan, Gary C.,Forman, John P.. Plasma prolactin level and risk of incident hypertension in postmenopausal women[J]. JOURNAL OF HYPERTENSION,2010,28(7):1400-1405.
APA Zhang, Luxia,Curhan, Gary C.,&Forman, John P..(2010).Plasma prolactin level and risk of incident hypertension in postmenopausal women.JOURNAL OF HYPERTENSION,28(7),1400-1405.
MLA Zhang, Luxia,et al."Plasma prolactin level and risk of incident hypertension in postmenopausal women".JOURNAL OF HYPERTENSION 28.7(2010):1400-1405.
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