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学科主题: 临床医学
题名:
Plasma prolactin level and risk of incident hypertension in postmenopausal women
作者: Zhang, Luxia1,2,3,4; Curhan, Gary C.1,2,3; Forman, John P.1,2,3
关键词: epidemiology ; human ; hypertension ; prolactin ; risk factor
刊名: JOURNAL OF HYPERTENSION
发表日期: 2010-07-01
DOI: 10.1097/HJH.0b013e328339f254
卷: 28, 期:7, 页:1400-1405
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ARTERIAL BLOOD-PRESSURE ; RENAL-FUNCTION ; BREAST-CANCER ; HYPERPROLACTINEMIA ; PREMENOPAUSAL ; QUESTIONNAIRE ; INFLAMMATION ; PREGNANCY ; ESTROGEN ; ADHESION
英文摘要:

Background Laboratory and cross-sectional human studies suggest a potential role for prolactin in the pathogenesis of hypertension; however, the prospective association between prolactin and hypertension has not been previously reported.

Methods We prospectively examined the association between daytime plasma prolactin levels and the risk of incident hypertension among 874 postmenopausal women who were participants of the Nurses′ Health Study. Cox proportional hazards regression models were used to adjust for potential confounders.

Results We identified 183 incident cases of hypertension during 8 years of follow-up. After adjusting for potential confounders, the relative risk of hypertension for a 1-standard deviation higher plasma prolactin was 1.31 (95% confidence interval 1.05-1.62). Compared with women with plasma prolactin levels of 8.0 ng/ml or below, the multivariable relative risk of incident hypertension for those with prolactin levels above 8.0 ng/ml was 1.34 (95% confidence interval 0.90-1.99).

Conclusion A higher daytime plasma prolactin level is independently associated with an increased risk of incident hypertension among postmenopausal women. J Hypertens 28: 1400-1405 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 0535401T ; CA87969 ; HL079929
项目资助者: American Heart Association ; National Institutes of Health ; Beijing Municipal Science and Technology Commission ; International Society of Nephrology
WOS记录号: WOS:000279579800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55085
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Harvard Univ, Sch Med, Boston, MA USA
2.Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA
3.Brigham & Womens Hosp, Dept Med, Div Renal, Boston, MA 02115 USA
4.Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Luxia,Curhan, Gary C.,Forman, John P.. Plasma prolactin level and risk of incident hypertension in postmenopausal women[J]. JOURNAL OF HYPERTENSION,2010,28(7):1400-1405.
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