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学科主题: 临床医学
题名:
MFAP3L activation promotes colorectal cancer cell invasion and metastasis
作者: Lou, Xiaomin1; Kang, Bin1; Zhang, Jun1; Hao, Chunyi2; Tian, Xiuyun2; Li, Wenmei2; Xu, Ningzhi3,4; Lu, Youyong2; Liu, Siqi1
关键词: MFAP3L ; Protein kinase ; Metastasis ; Colorectal cancer
刊名: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
发表日期: 2014-09-01
DOI: 10.1016/j.bbadis.2014.04.006
卷: 1842, 期:9, 页:1423-1432
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: GROWTH-FACTOR RECEPTOR ; NUCLEAR-LOCALIZATION ; TYROSINE KINASES ; GENE SIGNATURE ; PROTEIN ; EXPRESSION ; CONTRIBUTES ; PATHWAYS ; SURVIVAL ; MOTILITY
英文摘要:

An abundance of microfibril-associated glycoprotein 3-like (MFAP3L) significantly correlates with distant metastasis in colorectal cancer (CRC), although the mechanism has yet to be explained. In this study, we observed that MFAP3L knock-down resulted in reduced CRC cell invasion and hepatic metastasis. We evaluated the cellular location and biochemical functions of MFAP3L and found that this protein was primarily localized in the nucleus of CRC cells and acted as a protein kinase. When EGFR translocated into the nucleus upon stimulation with EGF, MFAP3L was phosphofylated at Tyr287 within its SH2 motif, and the activated form of MFAP3L phosphorylated ERK2 at Thr185 and Tyr187. Moreover, the metastatic behavior of CRC cells in vitro and in vivo could be partially explained by activation of the nuclear ERK pathway through MFAP3L phosphorylation. Hence, we experimentally demonstrated for the first time that MFAP3L likely participates in the nuclear signaling of EGFR and ERK2 and acts as a novel nuclear kinase that impacts CRC metastasis. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2012AA020206 ; 2009CB522200
项目资助者: National High Technology Research and Development Program of China ; Major State Basic Research Development Program of China
WOS记录号: WOS:000340975400014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55086
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Key Lab Carcinogenesis & Translat Res,Lab Mol Onc, Beijing 100142, Peoples R China
3.Chinese Acad Med Sci, Inst Canc, Lab Cell & Mol Biol, Beijing 100021, Peoples R China
4.Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China

Recommended Citation:
Lou, Xiaomin,Kang, Bin,Zhang, Jun,et al. MFAP3L activation promotes colorectal cancer cell invasion and metastasis[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2014,1842(9):1423-1432.
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