IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
MFAP3L activation promotes colorectal cancer cell invasion and metastasis
Lou, Xiaomin1; Kang, Bin1; Zhang, Jun1; Hao, Chunyi2; Tian, Xiuyun2; Li, Wenmei2; Xu, Ningzhi3,4; Lu, Youyong2; Liu, Siqi1
关键词Mfap3l Protein Kinase Metastasis Colorectal Cancer
刊名BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
2014-09-01
DOI10.1016/j.bbadis.2014.04.006
1842期:9页:1423-1432
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]GROWTH-FACTOR RECEPTOR ; NUCLEAR-LOCALIZATION ; TYROSINE KINASES ; GENE SIGNATURE ; PROTEIN ; EXPRESSION ; CONTRIBUTES ; PATHWAYS ; SURVIVAL ; MOTILITY
英文摘要

An abundance of microfibril-associated glycoprotein 3-like (MFAP3L) significantly correlates with distant metastasis in colorectal cancer (CRC), although the mechanism has yet to be explained. In this study, we observed that MFAP3L knock-down resulted in reduced CRC cell invasion and hepatic metastasis. We evaluated the cellular location and biochemical functions of MFAP3L and found that this protein was primarily localized in the nucleus of CRC cells and acted as a protein kinase. When EGFR translocated into the nucleus upon stimulation with EGF, MFAP3L was phosphofylated at Tyr287 within its SH2 motif, and the activated form of MFAP3L phosphorylated ERK2 at Thr185 and Tyr187. Moreover, the metastatic behavior of CRC cells in vitro and in vivo could be partially explained by activation of the nuclear ERK pathway through MFAP3L phosphorylation. Hence, we experimentally demonstrated for the first time that MFAP3L likely participates in the nuclear signaling of EGFR and ERK2 and acts as a novel nuclear kinase that impacts CRC metastasis. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000340975400014
项目编号2012AA020206 ; 2009CB522200
资助机构National High Technology Research and Development Program of China ; Major State Basic Research Development Program of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55086
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_肝胆胰外二科
北京大学临床肿瘤学院_高技术实验室
作者单位1.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Key Lab Carcinogenesis & Translat Res,Lab Mol Onc, Beijing 100142, Peoples R China
3.Chinese Acad Med Sci, Inst Canc, Lab Cell & Mol Biol, Beijing 100021, Peoples R China
4.Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China
推荐引用方式
GB/T 7714
Lou, Xiaomin,Kang, Bin,Zhang, Jun,et al. MFAP3L activation promotes colorectal cancer cell invasion and metastasis[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2014,1842(9):1423-1432.
APA Lou, Xiaomin.,Kang, Bin.,Zhang, Jun.,Hao, Chunyi.,Tian, Xiuyun.,...&Liu, Siqi.(2014).MFAP3L activation promotes colorectal cancer cell invasion and metastasis.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1842(9),1423-1432.
MLA Lou, Xiaomin,et al."MFAP3L activation promotes colorectal cancer cell invasion and metastasis".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1842.9(2014):1423-1432.
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