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Gene-Gene Interaction Between COMT and MAOA Potentially Predicts the Intelligence of Attention-Deficit Hyperactivity Disorder Boys in China
Qian, Qiu-Jin1; Yang, Li1; Wang, Yu-Feng1; Zhang, Hao-Bo1; Guan, Li-Li1; Chen, Yun1; Ji, Ning1; Liu, Lu1; Faraone, S. V.2,3
关键词Attention Deficit Hyperactivity Disorder Catechol-o-methyltransferase Monoamine Oxidase a Intelligence Gene-gene Interaction Polymorphism
刊名BEHAVIOR GENETICS
2010-05-01
DOI10.1007/s10519-009-9314-8
40期:3页:357-365
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology ; Social Sciences
类目[WOS]Behavioral Sciences ; Genetics & Heredity ; Psychology, Multidisciplinary
资助者National Natural Sciences Foundation of China ; Commonweal Sciences Foundation, Ministry of Health, China ; National Foundation, Ministry of Science and Technology, China ; National Natural Sciences Foundation of China ; Commonweal Sciences Foundation, Ministry of Health, China ; National Foundation, Ministry of Science and Technology, China
研究领域[WOS]Behavioral Sciences ; Genetics & Heredity ; Psychology
关键词[WOS]CATECHOL-O-METHYLTRANSFERASE ; MONOAMINE-OXIDASE-A ; DEFICIT/HYPERACTIVITY DISORDER ; FUNCTIONAL POLYMORPHISM ; WORKING-MEMORY ; COGNITIVE FUNCTION ; PROMOTER POLYMORPHISM ; HEALTHY-VOLUNTEERS ; ENZYME-ACTIVITY ; FRONTAL-CORTEX
英文摘要

The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism (Val158Met) affecting the activity of the enzyme, and the monoamine oxidase A (MAOA) gene contains a VNTR polymorphism (MAOA-uVNTR) that affects the transcription of the gene. COMT and MAOA each contribute to the enzymatic degradation of dopamine and noradrenaline. Prefrontal cortical (PFC) function, which plays an important role in individual cognitive abilities, including intelligence, is modulated by dopamine. Since our previous association studies between attention deficit hyperactivity disorder (ADHD) and these two functional polymorphisms consistently showed the low activity alleles were preferentially transmitted to inattentive ADHD boys, the goal of the present study was to test the hypothesis that the interaction between COMT Val158Met and MAOA-uVNTR may affect the intelligence in a clinical sample of Chinese male ADHD subjects (n = 264). We found that the COMT x MAOA interaction significantly predicted full scale (FSIQ) and performance (PIQ) IQ scores (P = 0.039, 0.011); the MAOA-uVNTR significantly predicted FSIQ, PIQ and verbal IQ (VIQ) (P = 0.009, 0.019, 0.038); COMT Val158Met independently had no effect on any of the IQ scores. Only the COMT x MAOA interaction for PIQ remained significant after a Bonferroni correction. Among all combined genotypes, the valval-3R genotype predicted higher intelligence, (average 106.7 +/- A 1.6, 95% C.I. 103.7-109.8 for FSIQ), and the valval-4R predicted lower intelligence (average 98.0 +/- A 2.3, 95% C.I. 93.5-102.6 for FSIQ). These results suggest that there is an inverted U-shaped relationship between intelligence and dopaminergic activity in our sample. Our finding that gene-gene interaction between COMT and MAOA predicts the intelligence of ADHD boys in China is intriguing but requires replication in other samples.

语种英语
所属项目编号30770774 ; 200802073 ; 2007BAI17B03
资助者National Natural Sciences Foundation of China ; Commonweal Sciences Foundation, Ministry of Health, China ; National Foundation, Ministry of Science and Technology, China ; National Natural Sciences Foundation of China ; Commonweal Sciences Foundation, Ministry of Health, China ; National Foundation, Ministry of Science and Technology, China
WOS记录号WOS:000276603900009
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55093
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Inst Mental Hlth, Beijing 100191, Peoples R China
2.SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY USA
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Qian, Qiu-Jin,Yang, Li,Wang, Yu-Feng,et al. Gene-Gene Interaction Between COMT and MAOA Potentially Predicts the Intelligence of Attention-Deficit Hyperactivity Disorder Boys in China[J]. BEHAVIOR GENETICS,2010,40(3):357-365.
APA Qian, Qiu-Jin.,Yang, Li.,Wang, Yu-Feng.,Zhang, Hao-Bo.,Guan, Li-Li.,...&Faraone, S. V..(2010).Gene-Gene Interaction Between COMT and MAOA Potentially Predicts the Intelligence of Attention-Deficit Hyperactivity Disorder Boys in China.BEHAVIOR GENETICS,40(3),357-365.
MLA Qian, Qiu-Jin,et al."Gene-Gene Interaction Between COMT and MAOA Potentially Predicts the Intelligence of Attention-Deficit Hyperactivity Disorder Boys in China".BEHAVIOR GENETICS 40.3(2010):357-365.
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