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Intestinal Permeability of Sesquiterpenes in the Caco-2 Cell Monolayer Model
Wu, Qi; Zhao, Bo; Yang, Xiu-Wei1; Xu, Wei; Zhang, Peng; Zou, Lei; Zhang, Lian-Xue
关键词Sesquiterpenes Intestinal Permeability Caco-2 Cell Monolayer
刊名PLANTA MEDICA
2010-03-01
DOI10.1055/s-0029-1186195
76期:4页:319-324
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]ABSORPTION ; TRANSPORT ; CONSTITUENTS ; INHIBITION
英文摘要

The intestinal permeability of eight sesquiterpenes which are active constituents of some traditional Chinese medicines, were studied by using the Caco-2 cell monolayer; they include tanacetin, artesin, magnolialide, crossostephin, atractylon, isocalamenediol (ICL), bisabolangelone (BSE) and (3R)-des-O-methyllasiodiplodin (DML). The bidirectional permeability of the eight sesquiterpenes was studied from the apical (AP) side to the basolateral (BL) side or from the BL side to the AP side. The eight compounds were assayed by HPLC. Transport parameters and apparent permeability coefficients (P(app)) were then calculated. The bidirectional P(app) values of the eight compounds were compared with those of propranolol, a marker of high permeability and transcellular transport. The transport of the eight sesquiterpenes was concentration-dependent in the range of 10-200 mu M. Lower recoveries of ICL, BSE and DML than other sesquiterpenes were found during transport. The results indicated that all the sesquiterpenes are well absorbed mainly by the passive diffusion via the transcellular pathway and metabolism may be involved during the absorption of ICL, BSE and DML.

语种英语
WOS记录号WOS:000275033200002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55099
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Beijing 100191, Peoples R China
2.Jilin Agr Univ, Coll Chinese Med Mat, Changchun, Peoples R China
3.Natl Pharmaceut R&D Co Ltd, Beijing, Peoples R China
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GB/T 7714
Wu, Qi,Zhao, Bo,Yang, Xiu-Wei,et al. Intestinal Permeability of Sesquiterpenes in the Caco-2 Cell Monolayer Model[J]. PLANTA MEDICA,2010,76(4):319-324.
APA Wu, Qi.,Zhao, Bo.,Yang, Xiu-Wei.,Xu, Wei.,Zhang, Peng.,...&Zhang, Lian-Xue.(2010).Intestinal Permeability of Sesquiterpenes in the Caco-2 Cell Monolayer Model.PLANTA MEDICA,76(4),319-324.
MLA Wu, Qi,et al."Intestinal Permeability of Sesquiterpenes in the Caco-2 Cell Monolayer Model".PLANTA MEDICA 76.4(2010):319-324.
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