北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 天然药物学系  > 期刊论文
学科主题: 药学
题名:
Intestinal Permeability of Sesquiterpenes in the Caco-2 Cell Monolayer Model
作者: Wu, Qi; Zhao, Bo; Yang, Xiu-Wei1; Xu, Wei; Zhang, Peng; Zou, Lei; Zhang, Lian-Xue
关键词: sesquiterpenes ; intestinal permeability ; Caco-2 cell monolayer
刊名: PLANTA MEDICA
发表日期: 2010-03-01
DOI: 10.1055/s-0029-1186195
卷: 76, 期:4, 页:319-324
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: ABSORPTION ; TRANSPORT ; CONSTITUENTS ; INHIBITION
英文摘要:

The intestinal permeability of eight sesquiterpenes which are active constituents of some traditional Chinese medicines, were studied by using the Caco-2 cell monolayer; they include tanacetin, artesin, magnolialide, crossostephin, atractylon, isocalamenediol (ICL), bisabolangelone (BSE) and (3R)-des-O-methyllasiodiplodin (DML). The bidirectional permeability of the eight sesquiterpenes was studied from the apical (AP) side to the basolateral (BL) side or from the BL side to the AP side. The eight compounds were assayed by HPLC. Transport parameters and apparent permeability coefficients (P(app)) were then calculated. The bidirectional P(app) values of the eight compounds were compared with those of propranolol, a marker of high permeability and transcellular transport. The transport of the eight sesquiterpenes was concentration-dependent in the range of 10-200 mu M. Lower recoveries of ICL, BSE and DML than other sesquiterpenes were found during transport. The results indicated that all the sesquiterpenes are well absorbed mainly by the passive diffusion via the transcellular pathway and metabolism may be involved during the absorption of ICL, BSE and DML.

语种: 英语
所属项目编号: 30672609 ; 2002AA2Z343C ; 2004AA2Z3783 ; 2006BAI06A01-02 ; Z0004105040311
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Sciences and Technology Program of China ; Beijing Municipal Special-Purpose Science Foundation of China
WOS记录号: WOS:000275033200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55099
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Beijing 100191, Peoples R China
2.Jilin Agr Univ, Coll Chinese Med Mat, Changchun, Peoples R China
3.Natl Pharmaceut R&D Co Ltd, Beijing, Peoples R China

Recommended Citation:
Wu, Qi,Zhao, Bo,Yang, Xiu-Wei,et al. Intestinal Permeability of Sesquiterpenes in the Caco-2 Cell Monolayer Model[J]. PLANTA MEDICA,2010,76(4):319-324.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, Qi]'s Articles
[Zhao, Bo]'s Articles
[Yang, Xiu-Wei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, Qi]‘s Articles
[Zhao, Bo]‘s Articles
[Yang, Xiu-Wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace