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Correlation between dynamic contrast-enhanced MRI and histopathology in the measurement of tumor and breast volume and their ratio in breast cancer patients: a prospective study
Liu Qian1; Ye Ling-ming1; Xu Ling2; Duan Xue-ning1; Zhao Jian-xin1; Liu Yin-hua1
关键词Breast Tumor Dynamic Contrast-enhanced Mri Preoperative Chemotherapy Breast Volume Breast Tumor Volume
刊名CHINESE MEDICAL JOURNAL
2012-11-05
DOI10.3760/cma.j.issn.0366-6999.2012.21.021
125期:21页:3856-3860
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者Bejing Municipal Science and Technology Commission ; Bejing Municipal Science and Technology Commission
研究领域[WOS]General & Internal Medicine
关键词[WOS]NEOADJUVANT CHEMOTHERAPY ; ACCURACY
英文摘要

Background Earlier studies have examined the association between the diameter of primary tumors measured by magnetic resonance imaging (MRI) and histopathology in breast cancer patients. However, the diameter does not completely describe the dimensions of the breast tumor or its volumetric proportion relative to the whole breast. The association between breast tumor volume/breast volume ratios measured by these two techniques has not been reported.

Methods Seventy-three patients were recruited from female patients with primary breast tumors admitted to our center between January and December 2010. They were divided into two groups. Group A (n=46) underwent modified radical mastectomy (MRM), and Group B (n=27) underwent preoperative neoadjuvant chemotherapy before MRM. They were examined by dynamic-contrast enhanced MRI (DCE-MRI) to measure breast volumes (BVs), tumor volumes (TVs), and tumor volume/breast volume ratios (TV/BV). These measurements were compared with histopathology results after MRM, and the associations between MRI and pathology were analyzed by linear regression and Bland-Altman analysis.

Results For Group A, the correlation coefficients for BVs, TVs, and TV/BV ratios measured by the two techniques were 0.938, 0.921, and 0.897 (all P<0.001), respectively. For Group B, the correlation coefficients for BVs, TVs, and TV/BV ratios were 0.936, 0.902, and 0.869 (all P<0.01), respectively. The results suggest statistically significant correlations between these parameters measured by the two techniques for both groups.

Conclusion For these patients, BVs, TVs, and TV/BV ratios measured by DCE-MRI significantly correlated with those determined by histopathology. Chin Med J 2012;125(21):3856-3860

语种英语
所属项目编号D090507043409010
资助者Bejing Municipal Science and Technology Commission ; Bejing Municipal Science and Technology Commission
WOS记录号WOS:000311265200021
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55100
专题北京大学第一临床医学院_普通外科
作者单位1.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Gen Surg, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Breast Dis Ctr, Dept Clin Oncol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Liu Qian,Ye Ling-ming,Xu Ling,et al. Correlation between dynamic contrast-enhanced MRI and histopathology in the measurement of tumor and breast volume and their ratio in breast cancer patients: a prospective study[J]. CHINESE MEDICAL JOURNAL,2012,125(21):3856-3860.
APA Liu Qian,Ye Ling-ming,Xu Ling,Duan Xue-ning,Zhao Jian-xin,&Liu Yin-hua.(2012).Correlation between dynamic contrast-enhanced MRI and histopathology in the measurement of tumor and breast volume and their ratio in breast cancer patients: a prospective study.CHINESE MEDICAL JOURNAL,125(21),3856-3860.
MLA Liu Qian,et al."Correlation between dynamic contrast-enhanced MRI and histopathology in the measurement of tumor and breast volume and their ratio in breast cancer patients: a prospective study".CHINESE MEDICAL JOURNAL 125.21(2012):3856-3860.
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