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学科主题临床医学
9q33.3, A Stress-Related Chromosome Region, Contributes to Reducing Lung Squamous Cell Carcinoma Risk
Xiao, Qin1,2; Gao, Shan3; Luo, Hui1; Fan, Wenguo4; Guo, Shicheng5,6; Yao, Hong7; Leng, Shuilong7,8; Xu, Zhenhua9; Tao, Tao10; Liu, Xingyan1; Zhang, Jingfang7; Zhang, Ming10; Li, Dongpei11; Xiao, Qin2
关键词Lung Squamous Cell Carcinoma Mapkap1 Snps Population Attributable Risk 9q33 3
刊名JOURNAL OF THORACIC ONCOLOGY
2014-07-01
DOI10.1097/JTO.0000000000000195
9期:7页:1041-1047
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Respiratory System
研究领域[WOS]Oncology ; Respiratory System
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; COMPLEX INTEGRITY ; CANCER ; GRP78 ; POLYMORPHISM ; PHOSPHORYLATION ; RS430397 ; HALLMARK ; RICTOR
英文摘要

Background: Human chromosome 9q33.3 is one of the most important loci for pathophysiological stresses with complex genetic traits. We hypothesized that the common single-nucleotide polymorphisms on this region may affect non-small-cell lung cancer risk.

Methods: We genotyped 43 single-nucleotide polymorphisms that span 13 genes on 9q33.3 in two independent cohorts: the discovery study including 485 cases and 532 controls (North China) and the replicative study including 1063 cases and 1247 controls (South China). Both of the discovery cohort and the replicative cohort were included in the combined study.

Results: In the discovery study, we identified a potential protective locus rs10118570 in mitogen-activated protein kinase associated protein 1 with a lower population attributable risk under logistical regression adjusted by age, gender, smoking, and drinking status (adjusted odds ratio [OR] 0.26, 95% confidence interval [CI] 0.10-0.71, p = 1.138 x 10(-3) for genotype GG in lung squamous cell carcinoma). This protective quality increased in a dose-dependent manner as genotype GG decreased (p(trend) = 9.675 x 10(-4)). Replicative and combined studies showed consistent association for this genotype (replicative: adjusted OR 0.36, 95% CI 0.20-0.66, p = 6.109 x 10(-4), p(trend) = 7.386 x 10(-4); combined: adjusted OR 0.33, 95% CI 0.18-0.55, p = 1.259 x 10(-6), p(trend) = 7.725 x 10(-6)).

Conclusion: We concluded that mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.

语种英语
WOS记录号WOS:000338025600026
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55102
专题北京大学深圳医院
作者单位1.Guangdong Med Coll, Dept Biochem, Key Lab Mol Diag, Dongguan, Peoples R China
2.Peking Univ, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr, Dept Transfus, Shenzhen, Peoples R China
3.Tianjin Univ, Sch Comp Sci & Technol, Tianjin 300072, Peoples R China
4.Sun Yat Sen Univ, Guanghua Sch Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou 510275, Guangdong, Peoples R China
5.Fudan Univ, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
6.Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China
7.Chinese Univ Hong Kong, Li Ka Shing Inst Med Sci, Stanley Ho Ctr Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China
8.Guangzhou Med Univ, Dept Human Anat, Guangzhou, Guangdong, Peoples R China
9.Univ Penn, Abramson Family Canc Res Inst, Dept Canc Biol, Canc Cell Biol Program, Philadelphia, PA 19104 USA
10.Shandong Prov Zibo Cent Hosp, Dept Canc, Ctr Clin Med Res, Zibo, Peoples R China
11.Georgia Regents Univ, Inst Mol Med & Genet, Augusta, GA 30901 USA
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GB/T 7714
Xiao, Qin,Gao, Shan,Luo, Hui,et al. 9q33.3, A Stress-Related Chromosome Region, Contributes to Reducing Lung Squamous Cell Carcinoma Risk[J]. JOURNAL OF THORACIC ONCOLOGY,2014,9(7):1041-1047.
APA Xiao, Qin.,Gao, Shan.,Luo, Hui.,Fan, Wenguo.,Guo, Shicheng.,...&Xiao, Qin.(2014).9q33.3, A Stress-Related Chromosome Region, Contributes to Reducing Lung Squamous Cell Carcinoma Risk.JOURNAL OF THORACIC ONCOLOGY,9(7),1041-1047.
MLA Xiao, Qin,et al."9q33.3, A Stress-Related Chromosome Region, Contributes to Reducing Lung Squamous Cell Carcinoma Risk".JOURNAL OF THORACIC ONCOLOGY 9.7(2014):1041-1047.
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