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学科主题: 临床医学
题名:
9q33.3, A Stress-Related Chromosome Region, Contributes to Reducing Lung Squamous Cell Carcinoma Risk
作者: Xiao, Qin1,2; Gao, Shan3; Luo, Hui1; Fan, Wenguo4; Guo, Shicheng5,6; Yao, Hong7; Leng, Shuilong7,8; Xu, Zhenhua9; Tao, Tao10; Liu, Xingyan1; Zhang, Jingfang7; Zhang, Ming10; Li, Dongpei11; Xiao, Qin2
关键词: Lung squamous cell carcinoma ; MAPKAP1 ; SNPs ; Population attributable risk ; 9q33 ; 3
刊名: JOURNAL OF THORACIC ONCOLOGY
发表日期: 2014-07-01
DOI: 10.1097/JTO.0000000000000195
卷: 9, 期:7, 页:1041-1047
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Respiratory System
研究领域[WOS]: Oncology ; Respiratory System
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; COMPLEX INTEGRITY ; CANCER ; GRP78 ; POLYMORPHISM ; PHOSPHORYLATION ; RS430397 ; HALLMARK ; RICTOR
英文摘要:

Background: Human chromosome 9q33.3 is one of the most important loci for pathophysiological stresses with complex genetic traits. We hypothesized that the common single-nucleotide polymorphisms on this region may affect non-small-cell lung cancer risk.

Methods: We genotyped 43 single-nucleotide polymorphisms that span 13 genes on 9q33.3 in two independent cohorts: the discovery study including 485 cases and 532 controls (North China) and the replicative study including 1063 cases and 1247 controls (South China). Both of the discovery cohort and the replicative cohort were included in the combined study.

Results: In the discovery study, we identified a potential protective locus rs10118570 in mitogen-activated protein kinase associated protein 1 with a lower population attributable risk under logistical regression adjusted by age, gender, smoking, and drinking status (adjusted odds ratio [OR] 0.26, 95% confidence interval [CI] 0.10-0.71, p = 1.138 x 10(-3) for genotype GG in lung squamous cell carcinoma). This protective quality increased in a dose-dependent manner as genotype GG decreased (p(trend) = 9.675 x 10(-4)). Replicative and combined studies showed consistent association for this genotype (replicative: adjusted OR 0.36, 95% CI 0.20-0.66, p = 6.109 x 10(-4), p(trend) = 7.386 x 10(-4); combined: adjusted OR 0.33, 95% CI 0.18-0.55, p = 1.259 x 10(-6), p(trend) = 7.725 x 10(-6)).

Conclusion: We concluded that mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.

语种: 英语
所属项目编号: 81071697 ; 12C22061657/2012J4100075 ; S2011040003694 ; XB1382
项目资助者: National Natural Science Foundation of China ; Research Project of Science and Information Technology of Guangzhou City ; Natural Science Foundation of Guangdong Province Grant ; Research Project of Initial for Talent Research in Guangdong Medical College
WOS记录号: WOS:000338025600026
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55102
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Guangdong Med Coll, Dept Biochem, Key Lab Mol Diag, Dongguan, Peoples R China
2.Peking Univ, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr, Dept Transfus, Shenzhen, Peoples R China
3.Tianjin Univ, Sch Comp Sci & Technol, Tianjin 300072, Peoples R China
4.Sun Yat Sen Univ, Guanghua Sch Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou 510275, Guangdong, Peoples R China
5.Fudan Univ, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
6.Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China
7.Chinese Univ Hong Kong, Li Ka Shing Inst Med Sci, Stanley Ho Ctr Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China
8.Guangzhou Med Univ, Dept Human Anat, Guangzhou, Guangdong, Peoples R China
9.Univ Penn, Abramson Family Canc Res Inst, Dept Canc Biol, Canc Cell Biol Program, Philadelphia, PA 19104 USA
10.Shandong Prov Zibo Cent Hosp, Dept Canc, Ctr Clin Med Res, Zibo, Peoples R China
11.Georgia Regents Univ, Inst Mol Med & Genet, Augusta, GA 30901 USA

Recommended Citation:
Xiao, Qin,Gao, Shan,Luo, Hui,et al. 9q33.3, A Stress-Related Chromosome Region, Contributes to Reducing Lung Squamous Cell Carcinoma Risk[J]. JOURNAL OF THORACIC ONCOLOGY,2014,9(7):1041-1047.
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