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学科主题口腔医学
In Situ Fabrication of Paclitaxel-Loaded Core-Crosslinked Micelles via Thiol-Ene "Click" Chemistry for Reduction-Responsive Drug Release
Huang, Ying1; Sun, Rui2; Luo, Qiaojie3; Wang, Ying2; Zhang, Kai3,4; Deng, Xuliang1; Zhu, Weipu2; Li, Xiaodong3; Shen, Zhiquan2
关键词Antitumor Biodegradability Drug Delivery Polycondensation Reduction Response Thiol-ene "click" Chemistry
刊名JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
2016
DOI10.1002/pola.27778
54期:1页:99-107
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]POLYMERIC MICELLES ; COPOLYMERS SYNTHESIS ; DOXORUBICIN DELIVERY ; REVERSIBLE DISULFIDE ; GLYCOL) HYDROGELS ; BLOCK-COPOLYMERS ; CATIONIC POLYMER ; NANOPARTICLES ; PH ; MICELLIZATION
英文摘要

In this study, a facile method to fabricate reduction-responsive core-crosslinked micelles via in situ thiol-ene "click" reaction was reported. A series of biodegradable poly (ether-ester)s with multiple pendent mercapto groups were first synthesized by melt polycondensation of diol poly(ethylene glycol), 1,4-butanediol, and mercaptosuccinic acid using scandium trifluoromethanesulfonate [Sc(OTf)(3)] as the catalyst. Then paclitaxel (PTX)-loaded core-crosslinked (CCL) micelles were successfully prepared by in situ crosslinking hydrophobic polyester blocks in aqueous media via thiol-ene "click" chemistry using 2,2′-dithiodiethanol diacrylate as the crosslinker. These PTX-loaded CCL micelles with disulfide bonds exhibited reduction-responsive behaviors in the presence of dithiothreitol (DTT). The drug release profile of the PTX-loaded CCL micelles revealed that only a small amount of loaded PTX was released slowly in phosphate buffer solution (PBS) without DTT, while quick release was observed in the presence of 10.0 mM DTT. Cell count kit (CCK-8) assays revealed that the reduction-sensitive PTX-loaded CCL micelles showed high antitumor activity toward HeLa cells, which was significantly higher than that of reduction-insensitive counterparts and free PTX. This kind of biodegradable and biocompatible CCL micelles could serve as a bioreducible nanocarrier for the controlled antitumor drug release. (C) 2015 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000366404700010
项目编号21274121 ; 51173163 ; 2011CB606001 ; 2015QNA4036 ; 2011C12054
资助机构National Natural Science Foundation of China ; Major State Basic Research Project ; Fundamental Research Funds for the Central Universities ; Science and Technology Project of Zhoushan
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55107
专题北京大学口腔医学院
北京大学临床肿瘤学院_重症监护病区
作者单位1.Zhoushan Stomatol Hosp, Zhoushan 316000, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
3.Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Dept Polymer Sci & Engn, Hangzhou 310027, Zhejiang, Peoples R China
4.Zhejiang Univ, Coll Med, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Hangzhou 310006, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714
Huang, Ying,Sun, Rui,Luo, Qiaojie,et al. In Situ Fabrication of Paclitaxel-Loaded Core-Crosslinked Micelles via Thiol-Ene "Click" Chemistry for Reduction-Responsive Drug Release[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2016,54(1):99-107.
APA Huang, Ying.,Sun, Rui.,Luo, Qiaojie.,Wang, Ying.,Zhang, Kai.,...&Shen, Zhiquan.(2016).In Situ Fabrication of Paclitaxel-Loaded Core-Crosslinked Micelles via Thiol-Ene "Click" Chemistry for Reduction-Responsive Drug Release.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,54(1),99-107.
MLA Huang, Ying,et al."In Situ Fabrication of Paclitaxel-Loaded Core-Crosslinked Micelles via Thiol-Ene "Click" Chemistry for Reduction-Responsive Drug Release".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 54.1(2016):99-107.
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