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Peripheral electrical stimulation reversed the cell size reduction and increased BDNF level in the ventral tegmental area in chronic morphine-treated rats
Chu, Ning-ning1,2,3,4,5,6; Zuo, Yan-fang1,2,3,4,5,6; Meng, Li1,2,3,4,5,6; Lee, Dauid Yue-Wei; Han, Ji-sheng1,2,3,4,5,6; Cui, Cai-lian1,2,3,4,5,6
关键词Brain-derived Neurotrophic Factor (Bdnf) Dopaminergic Neuron Morphine Peripheral Electrical Stimulation (Pes) Ventral Tegmental Area (Vta)
刊名BRAIN RESEARCH
2007-11-28
DOI10.1016/j.brainres.2007.08.086
1182期:1页:90-98
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MESOLIMBIC DOPAMINE SYSTEM ; NEUROTROPHIC FACTOR ; NEUROFILAMENT PROTEINS ; COCAINE ADDICTION ; NEURONAL-ACTIVITY ; PARS COMPACTA ; 2 HZ ; WITHDRAWAL ; BRAIN ; OPIATE
英文摘要

Chronic morphine administration induces functional and morphological alterations in the mesolimbic dopamine system (MLDS), which is believed to be the neurobiological substrate of opiate addiction. Our previous studies have demonstrated that peripheral electrical stimulation (PES) can suppress morphine withdrawal syndrome and morphine-induced conditioned place preference (CPP) in rats. The present study was designed to investigate if PES could reverse the cell size reduction induced by chronic morphine treatment in the ventral tegmental area (VTA), which is an important area of the MLDS. Immunohistochemical observations showed that the cell size of dopaminergic neurons in the VTA reduced significantly in the chronic morphine-treated rats with a concomitant decrease in the number of BDNF-positive cells compared to the saline-treated rats. A much milder morphological change, accompanying with an increased number of BDNF-positive cells, was observed in dopaminergic neurons in the rats that received repeated 100 Hz PES after morphine withdrawal. In another experiment, enzyme-linked immunosorbent assay (ELISA) reconfirmed a significant up-regulation of BDNF protein level in the VTA in the rats received 100 Hz PES after morphine abstinence. These results indicate that PES could facilitate the morphological recovery of the VTA dopaminergic cells damaged by chronic morphine treatment and up-regulate the BDNF protein level in the VTA. Activation of endogenous BDNF by PES may play a role in the recovery of the injured dopaminergic neurons in the morphine addictive rats. (C) 2007 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000251702700009
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被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55120
专题基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Minist Educ, Beijing 100083, Peoples R China
2.Peking Univ, Neurosci Res Inst, Minist Publ Hlth, Beijing 100083, Peoples R China
3.Peking Univ, Minist Educ, Dept Neurobiol, Beijing 100083, Peoples R China
4.Peking Univ, Minist Publ Hlth, Dept Neurobiol, Beijing 100083, Peoples R China
5.Peking Univ, Key Lab Neurosci, Minist Educ, Beijing 100083, Peoples R China
6.Peking Univ, Key Lab Neurosci, Minist Publ Hlth, Beijing 100083, Peoples R China
7.Harvard Univ, McLean Hosp, Sch Med, Bioorgan & Nat Prod Lab, Belmont, MA 02478 USA
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GB/T 7714
Chu, Ning-ning,Zuo, Yan-fang,Meng, Li,et al. Peripheral electrical stimulation reversed the cell size reduction and increased BDNF level in the ventral tegmental area in chronic morphine-treated rats[J]. BRAIN RESEARCH,2007,1182(1):90-98.
APA Chu, Ning-ning,Zuo, Yan-fang,Meng, Li,Lee, Dauid Yue-Wei,Han, Ji-sheng,&Cui, Cai-lian.(2007).Peripheral electrical stimulation reversed the cell size reduction and increased BDNF level in the ventral tegmental area in chronic morphine-treated rats.BRAIN RESEARCH,1182(1),90-98.
MLA Chu, Ning-ning,et al."Peripheral electrical stimulation reversed the cell size reduction and increased BDNF level in the ventral tegmental area in chronic morphine-treated rats".BRAIN RESEARCH 1182.1(2007):90-98.
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