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学科主题: 临床医学
题名:
In vivo and in situ detection of colorectal cancer using Fourier transform infrared spectroscopy
作者: Li, Qing-Bo1; Xu, Zhi2; Zhang, Neng-Wei2; Zhang, Li1; Wang, Fan1; Yang, Li-Min1; Wang, Jian-Sheng3; Zhou, Su2; Zhang, Yuan-Fu1; Zhou, Xiao-Si2; Shi, Jing-Sen3; Wu, Jin-Guang1
关键词: Colorectal cancer ; Fourier transform infrared spectroscopy
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2005-01-21
卷: 11, 期:3, 页:327-330
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
英文摘要:

AIM: Real-time and rapid identification of the malignant tissue can be performed during or before surgical operation. Here we aimed to detect in vivo and in situ colorectal cancer by using Fourier transform infrared (FTIR) spectroscopy and fiber-optic technology.

METHODS: A total of five patients with large intestine cancer were detected in vivo and in situ. Of them, three cases of colon cancer and one case of cecum cancer were detected intraoperatively and in vivo by using a FTIR spectrometer during surgical operation, and one case of rectum cancer was explored non-invasively and in vivo before the surgical operation. Normal and malignant colorectal tissues were detected in vivo and in situ using FTIR spectroscopy on the basis of fundamental studies.

RESULTS: There were significant differences between FTIR spectra of normal and malignant colorectal tissues detected in vivo and in situ. Experimental results revealed that the spectral characteristics of normal and malignant tissues found in vivo and in situ were similar to those obtained from in vitro measurement in our previous fundamental research.

CONCLUSION: FTIR fiber-optic attenuated total reflectance (ATR) spectroscopy can identify in situ and in vivo colorectal cancer. FTIR spectroscopic method with fiber optics is a non-invasive, rapid, accurate and in vivo cancer detection technique in clinical diagnosis. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30371604 ; 2002CCA01900
项目资助者: National Natural Science Foundation of China ; State Key Project of China
WOS记录号: WOS:000208224000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55121
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: 1.Peking Univ, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100083, Peoples R China
3.Xi An Jiao Tong Univ, Hosp 1, Dept Surg Oncol, Xian 710061, Shaanxi Provinc, Peoples R China

Recommended Citation:
Li, Qing-Bo,Xu, Zhi,Zhang, Neng-Wei,et al. In vivo and in situ detection of colorectal cancer using Fourier transform infrared spectroscopy[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2005,11(3):327-330.
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