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学科主题: 临床医学
题名:
Impact of Anemia and Dual Antiplatelet Therapy on Mortality in Patients Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents
作者: Wang, Huili1,2; Yang, Yuan3; Ma, Lufeng1; Wang, Xian4; Zhang, Jun5; Fu, Jinguo5; Zhang, Shouyan6; Zhang, Ling1; Hu, Dayi7; Ding, Rongjing7
刊名: SCIENTIFIC REPORTS
发表日期: 2015-11-25
DOI: 10.1038/srep17213
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ASSOCIATION TASK-FORCE ; BARE-METAL STENTS ; MYOCARDIAL REVASCULARIZATION ; PRACTICE GUIDELINES ; ARTERY-DISEASE ; RISK ; TERM ; METAANALYSIS ; HEMOGLOBIN ; THROMBOSIS
英文摘要:

The objective was to assess the impact of baseline anemia on all-cause mortality and whether 12-month dual antiplatelet therapy (DAPT) affects 1-year mortality linked to anemia in patients after percutaneous coronary intervention (PCI) with drug-eluting stents (DES). 4109 enrolled patients divided into three groups based on their pre-procedural hemoglobin (Hb) level: Hb < 100 mg/L represented moderate-severe anemia; 100 mg/L <= Hb < 120 mg/L for women and 100 mg/L <= Hb < 130 mg/L for men represented mild anemia; Hb >= 120 mg/L for women and Hb >= 130 mg/L for men represented no anemia. DAPT medications were prescribed when patients were discharged. There were significant differences in 30-day and 1-year mortality between moderate-severe anemia and no anemia patients (HR 8.05, 95% CI 1.46 to 44.33, P = 0.017; HR 3.93, 95% CI 1.11 to 13.98, P = 0.034), and in long-term mortality between anemia and no anemia groups (HR 1.82, 95% CI 1.17 to 2.83, P = 0.008 for mild anemia; HR 3.19,95% CI 1.29 to 7.86, P = 0.012 for moderate-severe anemia). There was not significant interaction between 12-month DAPT and anemia on mortality in anemic patients (P for interaction >0.05). Anemia shows association with increased all-cause mortality in patients undergoing PCI. Twelve-month DAPT does not show synergy with anemia to increase the risk of all-cause 1-year mortality in anemic patients after PCI.

语种: 英语
WOS记录号: WOS:000365335900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55127
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Capital Med Univ, Sch Publ Hlth, Beijing, Peoples R China
2.Capital Med Univ, Sch Gen Practice & Continuing Educ, Beijing, Peoples R China
3.Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing, Peoples R China
4.Beijing Univ, Chinese Med Dongzhimen Hosp, Dept Cardiol, Beijing 100871, Peoples R China
5.Cangzhou Cent Hosp, Dept Cardiol, Cangzhou, Hebei Province, Peoples R China
6.Zhengzhou Univ, Luoyang Cent Hosp, Dept Cardiol, Luoyang, Henan Province, Peoples R China
7.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Huili,Yang, Yuan,Ma, Lufeng,et al. Impact of Anemia and Dual Antiplatelet Therapy on Mortality in Patients Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents[J]. SCIENTIFIC REPORTS,2015,5.
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