IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Impact of Anemia and Dual Antiplatelet Therapy on Mortality in Patients Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents
Wang, Huili1,2; Yang, Yuan3; Ma, Lufeng1; Wang, Xian4; Zhang, Jun5; Fu, Jinguo5; Zhang, Shouyan6; Zhang, Ling1; Hu, Dayi7; Ding, Rongjing7
刊名SCIENTIFIC REPORTS
2015-11-25
DOI10.1038/srep17213
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ASSOCIATION TASK-FORCE ; BARE-METAL STENTS ; MYOCARDIAL REVASCULARIZATION ; PRACTICE GUIDELINES ; ARTERY-DISEASE ; RISK ; TERM ; METAANALYSIS ; HEMOGLOBIN ; THROMBOSIS
英文摘要

The objective was to assess the impact of baseline anemia on all-cause mortality and whether 12-month dual antiplatelet therapy (DAPT) affects 1-year mortality linked to anemia in patients after percutaneous coronary intervention (PCI) with drug-eluting stents (DES). 4109 enrolled patients divided into three groups based on their pre-procedural hemoglobin (Hb) level: Hb < 100 mg/L represented moderate-severe anemia; 100 mg/L <= Hb < 120 mg/L for women and 100 mg/L <= Hb < 130 mg/L for men represented mild anemia; Hb >= 120 mg/L for women and Hb >= 130 mg/L for men represented no anemia. DAPT medications were prescribed when patients were discharged. There were significant differences in 30-day and 1-year mortality between moderate-severe anemia and no anemia patients (HR 8.05, 95% CI 1.46 to 44.33, P = 0.017; HR 3.93, 95% CI 1.11 to 13.98, P = 0.034), and in long-term mortality between anemia and no anemia groups (HR 1.82, 95% CI 1.17 to 2.83, P = 0.008 for mild anemia; HR 3.19,95% CI 1.29 to 7.86, P = 0.012 for moderate-severe anemia). There was not significant interaction between 12-month DAPT and anemia on mortality in anemic patients (P for interaction >0.05). Anemia shows association with increased all-cause mortality in patients undergoing PCI. Twelve-month DAPT does not show synergy with anemia to increase the risk of all-cause 1-year mortality in anemic patients after PCI.

语种英语
WOS记录号WOS:000365335900001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55127
Collection北京大学第二临床医学院_心血管内科
作者单位1.Capital Med Univ, Sch Publ Hlth, Beijing, Peoples R China
2.Capital Med Univ, Sch Gen Practice & Continuing Educ, Beijing, Peoples R China
3.Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing, Peoples R China
4.Beijing Univ, Chinese Med Dongzhimen Hosp, Dept Cardiol, Beijing 100871, Peoples R China
5.Cangzhou Cent Hosp, Dept Cardiol, Cangzhou, Hebei Province, Peoples R China
6.Zhengzhou Univ, Luoyang Cent Hosp, Dept Cardiol, Luoyang, Henan Province, Peoples R China
7.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wang, Huili,Yang, Yuan,Ma, Lufeng,et al. Impact of Anemia and Dual Antiplatelet Therapy on Mortality in Patients Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents[J]. SCIENTIFIC REPORTS,2015,5.
APA Wang, Huili.,Yang, Yuan.,Ma, Lufeng.,Wang, Xian.,Zhang, Jun.,...&Ding, Rongjing.(2015).Impact of Anemia and Dual Antiplatelet Therapy on Mortality in Patients Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents.SCIENTIFIC REPORTS,5.
MLA Wang, Huili,et al."Impact of Anemia and Dual Antiplatelet Therapy on Mortality in Patients Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents".SCIENTIFIC REPORTS 5(2015).
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