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Prevalence of the Equol-Producer Phenotype and Its Relationship with Dietary Isoflavone and Serum Lipids in Healthy Chinese Adults
Liu, Baohua1; Qin, Liqiang2; Liu, Aiping1; Uchiyama, Shigeto3; Ueno, Tomomi3; Li, Xuetuo4; Wang, Peiyu1
关键词Equol Isoflavone Soy Serum Lipids
刊名JOURNAL OF EPIDEMIOLOGY
2010-09-01
DOI10.2188/jea.JE20090185
20期:5页:377-384
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
资助者National Natural Science Foundation of China ; State Education Ministry of China ; National Natural Science Foundation of China ; State Education Ministry of China
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]DAIDZEIN-METABOLIZING PHENOTYPES ; POSTMENOPAUSAL WOMEN ; LIGNAN EXCRETION ; SOY ISOFLAVONES ; BREAST-CANCER ; HABITUAL DIET ; SOYBEAN FOODS ; PLASMA ; CONSUMPTION ; MEN
英文摘要

Background: Studies have suggested that daidzein-metabolizing phenotypes have beneficial effects on a range of health outcomes. We investigated the prevalence of equol producers and the relationship of equol phenotype with habitual isoflavone consumption and serum lipid concentrations in 200 Chinese adults in Beijing.

Methods: After the baseline survey and dietary records, 200 healthy adults in Beijing were challenged with a soy-isoflavone supplement for 3 days; 24-hour urine samples were collected before and after the challenge. Isoflavones and their metabolites in urine were measured to determine equol phenotype. Serum lipids, uric acid, and other biochemical markers were also measured.

Results: Only 26.8% of the participants excreted equol when on a regular diet, as compared with 60.4% after the challenge. After the challenge, urinary isoflavonoid excretion increased in all participants, while equol excretion increased only in equol producers. Isoflavone intake was correlated with urinary isoflavone (range r = 0.49-0.58, P < 0.01). As compared with nonproducers, equol producers were less likely to consume cereals (P < 0.001). There was no significant correlation between serum lipids and isoflavone intake. Serum lipids were not significantly affected by equol phenotype.

Conclusions: Urinary equol excretion was detected in about 25% of participants under their usual dietary conditions. Their potential to produce equol was increased after the challenge. Urinary isoflavone levels may serve as a useful biomarker for isoflavone intake in populations. We observed an association between equol phenotype and cereal intake. Our findings also suggest that dietary isoflavone intake has no significant effect on serum lipids in healthy participants, regardless of equol phenotype.

语种英语
所属项目编号30872114 ; K5126829
资助者National Natural Science Foundation of China ; State Education Ministry of China ; National Natural Science Foundation of China ; State Education Ministry of China
WOS记录号WOS:000281834100005
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55131
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100191, Peoples R China
2.Soochow Univ, Sch Radiat Med & Publ Hlth, Dept Food Hyg & Nutr, Suzhou, Peoples R China
3.Otsuka Pharmaceut Co Ltd, Saga Nutraceut Res Inst, Saga, Japan
4.Otsuka China Investment Co Ltd, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liu, Baohua,Qin, Liqiang,Liu, Aiping,et al. Prevalence of the Equol-Producer Phenotype and Its Relationship with Dietary Isoflavone and Serum Lipids in Healthy Chinese Adults[J]. JOURNAL OF EPIDEMIOLOGY,2010,20(5):377-384.
APA Liu, Baohua.,Qin, Liqiang.,Liu, Aiping.,Uchiyama, Shigeto.,Ueno, Tomomi.,...&Wang, Peiyu.(2010).Prevalence of the Equol-Producer Phenotype and Its Relationship with Dietary Isoflavone and Serum Lipids in Healthy Chinese Adults.JOURNAL OF EPIDEMIOLOGY,20(5),377-384.
MLA Liu, Baohua,et al."Prevalence of the Equol-Producer Phenotype and Its Relationship with Dietary Isoflavone and Serum Lipids in Healthy Chinese Adults".JOURNAL OF EPIDEMIOLOGY 20.5(2010):377-384.
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