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Long-term survival of an allografted submandibular gland in a miniature swine model given immunosuppressant drugs
Ge, XY; Yu, GY; Cai, ZG; Mao, C
关键词Submandibular Gland Homologous Transplantation Miniature Swine
刊名BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
2006-04-01
DOI10.1016/j.bjoms.2005.04.004
44期:2页:146-151
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]KERATOCONJUNCTIVITIS SICCA ; XEROPHTHALMIA ; TRANSPLANTATION ; MANAGEMENT
英文摘要

We used a model of allografts of submandibular glands in miniature swine to test the requirements of immunosuppressants for the survival of such grafts. Animals in the first group (n=6) were given no immunosuppressant, and the submandibular glands were rejected within 7 days. Those in the low-dose group (n = 4) were treated with a low dose of cyclosporine, methylprednisolone, and azathioprine. The allografts were rejected on days 15, 17, 19, and 20. The animals in the high-dose group (n = 6) were treated with a high dose of cyclosporin, methylprednisolone, and azathioprine. Three allografts were rejected, on days 35, 48, and 60. One animal died from anaesthetic problems on day 30 after transplantation, and there were no signs of rejection in the allograft. The other two allografts survived for 100 days with secretory function and no signs of rejection. After we discontinued the immumosuppression on day 100, the two remaining allografts were rejected on days 121 and 128. Blood tests and biopsy specimens of the heart, lung, liver, and kidneys were normal in all animals that were given immumosuppressants. To our knowledge, this study is the first to describe long-term survival of allografted submandibular glands with secretory function in miniature swine. (c) 2005 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000236499400016
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55138
专题北京大学口腔医学院
作者单位Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
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GB/T 7714
Ge, XY,Yu, GY,Cai, ZG,et al. Long-term survival of an allografted submandibular gland in a miniature swine model given immunosuppressant drugs[J]. BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY,2006,44(2):146-151.
APA Ge, XY,Yu, GY,Cai, ZG,&Mao, C.(2006).Long-term survival of an allografted submandibular gland in a miniature swine model given immunosuppressant drugs.BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY,44(2),146-151.
MLA Ge, XY,et al."Long-term survival of an allografted submandibular gland in a miniature swine model given immunosuppressant drugs".BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY 44.2(2006):146-151.
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