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学科主题: 口腔医学
题名:
Long-term survival of an allografted submandibular gland in a miniature swine model given immunosuppressant drugs
作者: Ge, XY; Yu, GY; Cai, ZG; Mao, C
关键词: submandibular gland ; homologous transplantation ; miniature swine
刊名: BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
发表日期: 2006-04-01
DOI: 10.1016/j.bjoms.2005.04.004
卷: 44, 期:2, 页:146-151
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]: KERATOCONJUNCTIVITIS SICCA ; XEROPHTHALMIA ; TRANSPLANTATION ; MANAGEMENT
英文摘要:

We used a model of allografts of submandibular glands in miniature swine to test the requirements of immunosuppressants for the survival of such grafts. Animals in the first group (n=6) were given no immunosuppressant, and the submandibular glands were rejected within 7 days. Those in the low-dose group (n = 4) were treated with a low dose of cyclosporine, methylprednisolone, and azathioprine. The allografts were rejected on days 15, 17, 19, and 20. The animals in the high-dose group (n = 6) were treated with a high dose of cyclosporin, methylprednisolone, and azathioprine. Three allografts were rejected, on days 35, 48, and 60. One animal died from anaesthetic problems on day 30 after transplantation, and there were no signs of rejection in the allograft. The other two allografts survived for 100 days with secretory function and no signs of rejection. After we discontinued the immumosuppression on day 100, the two remaining allografts were rejected on days 121 and 128. Blood tests and biopsy specimens of the heart, lung, liver, and kidneys were normal in all animals that were given immumosuppressants. To our knowledge, this study is the first to describe long-term survival of allografted submandibular glands with secretory function in miniature swine. (c) 2005 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000236499400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55138
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China

Recommended Citation:
Ge, XY,Yu, GY,Cai, ZG,et al. Long-term survival of an allografted submandibular gland in a miniature swine model given immunosuppressant drugs[J]. BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY,2006,44(2):146-151.
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