IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma
Hu, Kai1,2; Gan, Ye-Hua1,2; Li, Sheng-Lin1,2; Gao, Yan2,3; Wu, Deng-Cheng1,2; Wang, Cun-Yu4; Yu, Guang-Yan1,2
关键词Salivary Adenoid Cystic Carcinoma Metastasis Extracellular Signal-regulated Kinase 1/2 Migration Invasion
刊名ONCOLOGY REPORTS
2009
DOI10.3892/or_00000200
21期:1页:137-143
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of P.R. China ; National Science Foundation of Beijing, P.R. China ; National Natural Science Foundation of P.R. China ; National Science Foundation of Beijing, P.R. China
研究领域[WOS]Oncology
关键词[WOS]HUMAN BREAST-CANCER ; PROTEIN-KINASE ; CELL MOTILITY ; GROWTH-FACTOR ; TUMOR PROGRESSION ; MAP KINASE ; KAPPA-B ; PATHWAY ; GLANDS ; HEAD
英文摘要

Lung metastasis is one of the important characteristics of salivary adenoid cystic carcinoma (SACC). Although activation of extracellular signal-regulated kinase 1/2 (ERK 1/2) pathway may be associated with cancer progression in some malignant tumors, its roles in lung metastasis of SACC remains unclear. We examined the expression of activated ERK1/2 in SACC-LM with high king-metastatic rate and SACC-83 with low king-metastatic rate, as well as in the tissues from lung-metastatic and non-metastatic groups of SACC patients. Western blot analysis indicated that SACC-LM exhibited higher expression of activated ERK1/2 than SACC-83. Similarly, immunohistochemistry showed that expression of activated ERK1/2 was detected in 73% (8/11) of the primary tissues from SACC patients with lung metastasis, while only 25% (3/12) of the primary tissues from SACC patients without lung metastasis (P<0.05). Furthermore, we examined the effects of UO 126, a specific inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK), oil migration and invasion in SACC-LM cells, showing U0126 not only inactivated ERK1/2, but also inhibited migration and invasion of SACC-LM. The present findings suggested that the elevated expression of activated ERK1/2 may play a role in lung metastasis of salivary adenoid cystic carcinoma.

语种英语
所属项目编号30572050 ; 7062069
资助者National Natural Science Foundation of P.R. China ; National Science Foundation of Beijing, P.R. China ; National Natural Science Foundation of P.R. China ; National Science Foundation of Beijing, P.R. China
WOS记录号WOS:000262123200019
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55140
专题北京大学口腔医学院
作者单位1.Peking Univ, Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
3.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
4.Univ Calif Los Angeles, Sch Dent, Mol Signalling Lab, Div Oral Biol & Med, Los Angeles, CA 90095 USA
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GB/T 7714
Hu, Kai,Gan, Ye-Hua,Li, Sheng-Lin,et al. Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma[J]. ONCOLOGY REPORTS,2009,21(1):137-143.
APA Hu, Kai.,Gan, Ye-Hua.,Li, Sheng-Lin.,Gao, Yan.,Wu, Deng-Cheng.,...&Yu, Guang-Yan.(2009).Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma.ONCOLOGY REPORTS,21(1),137-143.
MLA Hu, Kai,et al."Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma".ONCOLOGY REPORTS 21.1(2009):137-143.
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