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A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei
Liang, Yong-hong1; Wang, Wei2; Yu, Si-wang1; Ye, Min1; He, Xiang-hui1; Gong, Ning-bo3,4; Lu, Yang3,4; Khan, Ikhlas A.2; Guo, De-an1,5
关键词Drynaria Fortunei Polypodiaceae Triterpenoid Chiratane Cytotoxic Activity
刊名FITOTERAPIA
2010-12-01
DOI10.1016/j.fitote.2010.06.013
81期:8页:988-991
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]DRYOPTERIS-CRASSIRHIZOMA ; SWERTIA-CHIRATA ; NMR-SPECTRA ; HOPANE ; CONSTITUENTS ; LEAVES
英文摘要

Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20 beta-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC(50) of 2.92 mu M, 1.08 mu M and 2.45 mu M, respectively. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000285281800005
项目编号985-2-063-112 ; 985-2-119-121
资助机构Program Changjiang Scholar and Innovative Team in University ; Peking University Health Science Center
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55141
专题北京大学药学院
北京大学药学院_化学生物学系
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Univ Mississippi, Sino US TCM Res Ctr, Natl Ctr Nat Prod Res, Inst Pharmaceut Sci, University, MS 38677 USA
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China
5.CAS, Shanghai Res Ctr Modernizat TCM, Shanghai Inst Mat Med, Shanghai, Peoples R China
推荐引用方式
GB/T 7714
Liang, Yong-hong,Wang, Wei,Yu, Si-wang,et al. A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei[J]. FITOTERAPIA,2010,81(8):988-991.
APA Liang, Yong-hong.,Wang, Wei.,Yu, Si-wang.,Ye, Min.,He, Xiang-hui.,...&Guo, De-an.(2010).A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei.FITOTERAPIA,81(8),988-991.
MLA Liang, Yong-hong,et al."A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei".FITOTERAPIA 81.8(2010):988-991.
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