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学科主题: 药学
题名:
A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei
作者: Liang, Yong-hong1; Wang, Wei2; Yu, Si-wang1; Ye, Min1; He, Xiang-hui1; Gong, Ning-bo3,4; Lu, Yang3,4; Khan, Ikhlas A.2; Guo, De-an1,5
关键词: Drynaria fortunei ; Polypodiaceae ; Triterpenoid ; Chiratane ; Cytotoxic activity
刊名: FITOTERAPIA
发表日期: 2010-12-01
DOI: 10.1016/j.fitote.2010.06.013
卷: 81, 期:8, 页:988-991
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DRYOPTERIS-CRASSIRHIZOMA ; SWERTIA-CHIRATA ; NMR-SPECTRA ; HOPANE ; CONSTITUENTS ; LEAVES
英文摘要:

Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20 beta-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC(50) of 2.92 mu M, 1.08 mu M and 2.45 mu M, respectively. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 985-2-063-112 ; 985-2-119-121
项目资助者: Program Changjiang Scholar and Innovative Team in University ; Peking University Health Science Center
WOS记录号: WOS:000285281800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55141
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Univ Mississippi, Sino US TCM Res Ctr, Natl Ctr Nat Prod Res, Inst Pharmaceut Sci, University, MS 38677 USA
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China
5.CAS, Shanghai Res Ctr Modernizat TCM, Shanghai Inst Mat Med, Shanghai, Peoples R China

Recommended Citation:
Liang, Yong-hong,Wang, Wei,Yu, Si-wang,et al. A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei[J]. FITOTERAPIA,2010,81(8):988-991.
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