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Down-regulation of TCF21 is associated with poor survival in clear cell renal cell carcinoma
Ye, Y. W.2,4; Jiang, Z. M.2; Li, W. H.2; Li, Z. S.1,3; Han, Y. H.2; Sun, L.1,3; Wang, Y.2; Xie, J.2; Liu, Y. C.2; Zhao, J.2; Tang, A. F.1,3; Li, X. X.2; Guan, Z. C.2; Gui, Y. T.2; Cai, Z. M.1,3
关键词Tcf21 Gene Expression Methylation Clear Cell Renal Cell Carcinoma
刊名NEOPLASMA
2012
DOI10.4149/neo_2012_076
59期:6页:599-605
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]TUMOR-SUPPRESSOR GENES ; DNA METHYLATION ; LUNG-CANCER ; PROMOTER METHYLATION ; KIDNEY ; HYPERMETHYLATION ; IDENTIFICATION ; PANEL ; HEAD
英文摘要

Transcription factor 21 (TCF21) has been identified as a candidate tumor suppressor at 6q23-q24 that is epigenetically inactivated in many types of human cancers. We recently found that TCF21 methylation level was significantly increased in clear cell renal cell carcinoma (ccRCC). The purpose of this study was to investigate the prognostic impact of TCF21 expression in ccRCC and analyze the relationship between TCF21 expression and methylation level. We used real-time PCR and immunohistochemical staining to detect the expression of TCF21, and used methylation specific-PCR (MS-PCR) to determine the methylation status of TCF21 in ccRCC samples and cell line 786-0. The results showed that TCF21 expression level in ccRCC samples was significantly lower than in normal adjacent tissue samples (NAT samples). The Kaplan-Meier survival analysis demonstrated that TCF21 was a significant prognosticator of cancer-specific survival (p=0.001). Furthermore, the DNA demethylating agent 5′-azacytidine restored part of TCF21 expression by suppressing TCF21 methylation in 786-0. The methylation level of TCF21 in ccRCC samples was much higher than in NAT samples. These results suggest that the expression of TCF21 was an independent prognostic factor for poor survival in patients with ccRCC. Aberrant methylation was an important reason for the down-regulation the expression of TCF21, and may be associated with tumorigenesis in ccRCC.

语种英语
WOS记录号WOS:000310820200001
项目编号201003099 ; CXB200903090055A ; CXB201005250016A ; CXB201005250017A ; CXC201005260001A
资助机构Science and Technology Program of Shenzhen ; Promotion Program for Shenzhen Key Laboratory ; Biobank of Complex Diseases in Shenzhen
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被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55142
专题北京大学深圳医院
北京大学基础医学院
北京大学第一临床医学院_妇产科
作者单位1.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen Key Lab Genitourinary Tumor, Shenzhen, Peoples R China
2.Peking Univ, Shenzhen Hosp, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Inst Urol,Shenzhen PKU HKUST Med Ctr, Shenzhen, Peoples R China
3.Shenzhen Univ, Inst Urogenital Dis, Shenzhen, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Thorac Surg, Shenzhen, Peoples R China
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Ye, Y. W.,Jiang, Z. M.,Li, W. H.,et al. Down-regulation of TCF21 is associated with poor survival in clear cell renal cell carcinoma[J]. NEOPLASMA,2012,59(6):599-605.
APA Ye, Y. W..,Jiang, Z. M..,Li, W. H..,Li, Z. S..,Han, Y. H..,...&Cai, Z. M..(2012).Down-regulation of TCF21 is associated with poor survival in clear cell renal cell carcinoma.NEOPLASMA,59(6),599-605.
MLA Ye, Y. W.,et al."Down-regulation of TCF21 is associated with poor survival in clear cell renal cell carcinoma".NEOPLASMA 59.6(2012):599-605.
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