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学科主题临床医学
Effects of primary metronidazole and clarithromycin resistance to Helicobacter pylori on omeprazole, metronidazole, and clarithromycin triple-therapy regimen in a region with high rates of metronidazole resistance
Wong, WM; Gu, Q; Wang, WH; Fung, FMY; Berg, DE; Lai, KC; Xia, HHX; Hu, WHC; Chan, CK; Chan, AOO; Yuen, MF; Hui, CK; Lam, SK; Wong, BCY
刊名CLINICAL INFECTIOUS DISEASES
2003-10-01
37期:7页:882-889
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Infectious Diseases ; Microbiology
研究领域[WOS]Immunology ; Infectious Diseases ; Microbiology
关键词[WOS]DUODENAL-ULCER ; ANTIMICROBIAL RESISTANCE ; DYSPEPTIC PATIENTS ; HIGH PREVALENCE ; UNITED-STATES ; RISK-FACTORS ; HONG-KONG ; INFECTION ; ERADICATION ; EFFICACY
英文摘要

The aim of this study was to investigate the effect of metronidazole resistance (MtzR) and clarithromycin resistance (ClaR) on the eradication rate for omeprazole, clarithromycin, and metronidazole triple-therapy regimen and on the development of posttherapy drug resistance in a region of high rates of MtzR. One hundred ninety-six Helicobacter pylori isolates were recovered from patients with duodenal ulcer, gastric ulcer, or nonulcer dyspepsia during upper endoscopy. The prevalences of MtzR, ClaR, and dual resistance were 37.8%, 13.8%, and 8.7%, respectively. The intention-to-treat eradication rates for metronidazole-susceptible (87.2% vs. 67.6%; P = .001) and clarithromycin-susceptible (86.4% vs. 40.7%; P < .001) strains were significantly higher than the rates for resistant strains. Multiple logistic regression analysis implicated younger age (! 40 years old), MtzR, ClaR, and the diagnosis of nonulcer dyspepsia as independent factors that predicted treatment failure. The rates of posttreatment MtzR, ClaR, and dual resistance were 88%, 88%, and 75%, respectively. MtxR and ClaR significantly affected the success of eradication therapy. Posttreatment rates of resistance were high and were related to the presence of pretreatment antibiotic resistance.

语种英语
WOS记录号WOS:000185677400002
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55145
专题北京大学第一临床医学院_大内科
作者单位1.Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
2.Beijing Med Univ, First Teaching Hosp, Dept Med, Beijing 100083, Peoples R China
3.Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
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GB/T 7714
Wong, WM,Gu, Q,Wang, WH,et al. Effects of primary metronidazole and clarithromycin resistance to Helicobacter pylori on omeprazole, metronidazole, and clarithromycin triple-therapy regimen in a region with high rates of metronidazole resistance[J]. CLINICAL INFECTIOUS DISEASES,2003,37(7):882-889.
APA Wong, WM.,Gu, Q.,Wang, WH.,Fung, FMY.,Berg, DE.,...&Wong, BCY.(2003).Effects of primary metronidazole and clarithromycin resistance to Helicobacter pylori on omeprazole, metronidazole, and clarithromycin triple-therapy regimen in a region with high rates of metronidazole resistance.CLINICAL INFECTIOUS DISEASES,37(7),882-889.
MLA Wong, WM,et al."Effects of primary metronidazole and clarithromycin resistance to Helicobacter pylori on omeprazole, metronidazole, and clarithromycin triple-therapy regimen in a region with high rates of metronidazole resistance".CLINICAL INFECTIOUS DISEASES 37.7(2003):882-889.
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