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学科主题: 临床医学
题名:
Quantitative EEG effects of topiramate
作者: Wang, WW; Li, JC; Wu, X
关键词: electroencephalography ; epilepsy ; topiramate
刊名: CLINICAL ELECTROENCEPHALOGRAPHY
发表日期: 2003-04-01
卷: 34, 期:2, 页:87-92
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Clinical Neurology
研究领域[WOS]: Engineering ; Neurosciences & Neurology
关键词[WOS]: EPILEPTIC PATIENTS ; FOCAL EPILEPSY ; PHARMACO-EEG ; LAMOTRIGINE ; VALPROATE ; VIGABATRIN ; GABAPENTIN ; VOLUNTEERS ; FREQUENCY
英文摘要:

Objective: The study is to invesigate the effect of topiramate (TPM) on EEG by means of quantitative pharmacoelectroencephalography (QPEEG).

Methods: One dose of TPM was administrated to epileptics and healthy adults. The EEG samples were obtained prior to and at regular intervals within the 24 hours following the administration of TPM. The EEG activity was processed with power spectral analysis.

Results: The power of slow wave, alpha 1 bands and total power increased after the administration of TPM, the power or slow wave in both occipital areas, and the total power of all scalp areas also increased. The percent of power increased at the theta band and alpha 1 band (healthy adults) or delta band, theta band (patients).

Conclusion: TPM can change the EEG background activity. These changes are different from other antiepileptic drugs.

语种: 英语
WOS记录号: WOS:000183016000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55146
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China

Recommended Citation:
Wang, WW,Li, JC,Wu, X. Quantitative EEG effects of topiramate[J]. CLINICAL ELECTROENCEPHALOGRAPHY,2003,34(2):87-92.
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