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学科主题临床医学
Quantitative EEG effects of topiramate
Wang, WW; Li, JC; Wu, X
关键词Electroencephalography Epilepsy Topiramate
刊名CLINICAL ELECTROENCEPHALOGRAPHY
2003-04-01
34期:2页:87-92
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Clinical Neurology
研究领域[WOS]Engineering ; Neurosciences & Neurology
关键词[WOS]EPILEPTIC PATIENTS ; FOCAL EPILEPSY ; PHARMACO-EEG ; LAMOTRIGINE ; VALPROATE ; VIGABATRIN ; GABAPENTIN ; VOLUNTEERS ; FREQUENCY
英文摘要

Objective: The study is to invesigate the effect of topiramate (TPM) on EEG by means of quantitative pharmacoelectroencephalography (QPEEG).

Methods: One dose of TPM was administrated to epileptics and healthy adults. The EEG samples were obtained prior to and at regular intervals within the 24 hours following the administration of TPM. The EEG activity was processed with power spectral analysis.

Results: The power of slow wave, alpha 1 bands and total power increased after the administration of TPM, the power or slow wave in both occipital areas, and the total power of all scalp areas also increased. The percent of power increased at the theta band and alpha 1 band (healthy adults) or delta band, theta band (patients).

Conclusion: TPM can change the EEG background activity. These changes are different from other antiepileptic drugs.

语种英语
WOS记录号WOS:000183016000006
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55146
专题北京大学第一临床医学院_神经内科
作者单位Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
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GB/T 7714
Wang, WW,Li, JC,Wu, X. Quantitative EEG effects of topiramate[J]. CLINICAL ELECTROENCEPHALOGRAPHY,2003,34(2):87-92.
APA Wang, WW,Li, JC,&Wu, X.(2003).Quantitative EEG effects of topiramate.CLINICAL ELECTROENCEPHALOGRAPHY,34(2),87-92.
MLA Wang, WW,et al."Quantitative EEG effects of topiramate".CLINICAL ELECTROENCEPHALOGRAPHY 34.2(2003):87-92.
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