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The serum levels of connective tissue growth factor in patients with systemic lupus erythematosus and lupus nephritis
Wang, F-M1,2,3; Yu, F.1,2,3; Tan, Y.1,2,3; Liu, G.1,2,3; Zhao, M-H1,2,3,4
关键词Systemic Lupus Erythematosus Lupus Nephritis Connective Tissue Growth Factor
刊名LUPUS
2014-06-01
DOI10.1177/0961203314524291
23期:7页:655-664
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
资助者Chinese 973 project ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Chinese 973 project ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
研究领域[WOS]Rheumatology
关键词[WOS]TO-MESENCHYMAL TRANSITION ; DIABETIC-NEPHROPATHY ; RENAL FIBROSIS ; FACTOR CTGF ; TUBULOINTERSTITIAL FIBROSIS ; EPITHELIAL-CELLS ; DISEASE-ACTIVITY ; FACTOR EXCRETION ; CHINESE PATIENTS ; MESANGIAL CELLS
英文摘要

Objective: The expression of connective tissue growth factor mRNA in human kidneys may serve as an early marker for lupus nephritis progression. Therefore, we speculated that connective tissue growth factor may be involved in the pathogenesis of systemic lupus erythematosus and lupus nephritis. In this study, we set out to investigate the associations between serum connective tissue growth factor levels and clinicopathological features of patients with systemic lupus erythematosus and lupus nephritis. Methods: Serum samples from patients with non-renal systemic lupus erythematosus, renal biopsy-proven lupus nephritis and healthy control subjects were detected by enzyme-linked immunosorbent assay for serum connective tissue growth factor levels. The associations between connective tissue growth factor levels and clinicopathological features of the patients were further analysed. Results: The levels of serum connective tissue growth factor in patients with non-renal systemic lupus erythematosus and lupus nephritis were both significantly higher than those in the normal control group (34.14 +/- 12.17 ng/ml vs. 22.8 +/- 3.0 ng/ml, p<0.001; 44.1 +/- 46.8 ng/ml vs. 22.8 +/- 3.0 ng/ml, p = 0.035, respectively). There was no significant difference of the serum connective tissue growth factor levels between non-renal systemic lupus erythematosus and lupus nephritis group (34.14 +/- 12.17 ng/ml vs. 44.1 +/- 46.8 ng/ml, p = 0.183). Serum connective tissue growth factor levels were significantly higher in lupus nephritis patients with the following clinical manifestations, including anaemia (51.3 +/- 51.4 ng/ml vs. 23.4 +/- 9.7 ng/ml, p<0.001) and acute renal failure (85.5 +/- 75.0 ng/ml vs. 31.2 +/- 21.8 ng/ml, p = 0.002). Serum connective tissue growth factor levels in class IV were significantly higher than that in class II, III and V (57.6 +/- 57.5 ng/ml vs. 18.7 +/- 6.4 ng/ml, p = 0.019; 57.6 +/- 57.5 ng/ml vs. 25.2 +/- 14.9 ng/ml, p = 0.006; 57.6 +/- 57.5 ng/ml vs. 30.5 +/- 21.3 ng/ml, p = 0.017, respectively). Serum connective tissue growth factor levels were significantly higher in those with both active/chronic lesions than those in those with active lesions only in either class IV (84.9 +/- 69.6 ng/ml vs. 40.0 +/- 40.2 ng/ml, p = 0.001) or in combination of class III and IV lupus nephritis (63.3 +/- 63.4 ng/ml vs. 38.3 +/- 37.9 ng/ml, p = 0.035, respectively). Serum connective tissue growth factor levels were negatively associated with estimated glomerular filtration rate (r = -0.46, p<0.001) and positively associated with interstitial inflammation (r = 0.309, p = 0.002) and interstitial fibrosis (r = 0.287, p = 0.004). Serum connective tissue growth factor level was a risk factor for doubling of serum creatinine in lupus nephritis (p<0.001, hazard ratio 1.015, 95% confidence intervals 1.008-1.022) in univariate analysis. Conclusions: Serum connective tissue growth factor levels were significantly higher in lupus and correlated with chronic renal interstitial injury and doubling of serum creatinine in patients with lupus nephritis.

语种英语
所属项目编号2012CB517702 ; 81021004 ; 81100497 ; 7102150
资助者Chinese 973 project ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Chinese 973 project ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号WOS:000339103900006
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55152
专题北京大学第一临床医学院_肾脏内科
作者单位1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
3.Peking Univ, Inst Nephrol, Dept Med, Hosp 1, Beijing 100034, Peoples R China
4.Peking Univ, Minist Educ China, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, F-M,Yu, F.,Tan, Y.,et al. The serum levels of connective tissue growth factor in patients with systemic lupus erythematosus and lupus nephritis[J]. LUPUS,2014,23(7):655-664.
APA Wang, F-M,Yu, F.,Tan, Y.,Liu, G.,&Zhao, M-H.(2014).The serum levels of connective tissue growth factor in patients with systemic lupus erythematosus and lupus nephritis.LUPUS,23(7),655-664.
MLA Wang, F-M,et al."The serum levels of connective tissue growth factor in patients with systemic lupus erythematosus and lupus nephritis".LUPUS 23.7(2014):655-664.
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