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Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice
Yoon, Kyung-Chul1,4; De Paiva, Cintia S.1; Qi, Hong1,3; Chen, Zhuo1; Farley, William J.1; Li, De-Quan1; Stern, Michael E.1,2; Pflugfelder, Stephen C.1
关键词Desiccating Stress Lacrimal Keratoconjunctivitis Non-obese Diabetic Mouse Sjogren&Prime s Syndrome
刊名JOURNAL OF AUTOIMMUNITY
2008-06-01
DOI10.1016/j.jaut.2007.09.003
30期:4页:212-221
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]PRIMARY BILIARY-CIRRHOSIS ; EXPERIMENTAL DRY EYE ; NOD MOUSE MODEL ; SJOGRENS-SYNDROME ; BARRIER DISRUPTION ; SALIVARY-GLAND ; TEAR FLUID ; EXPRESSION ; DISEASE ; EXOCRINOPATHY
英文摘要

The non-obese diabetic (NOD) mouse is prone to develop autoimmune disease, including Sjogren′s syndrome. The purpose of this study was to determine if desiccating environmental stress exacerbates the development of Sjogren′s syndrome-like lacrimal keratoconjunctivitis in the NOD.B10.H2(b) mouse. Four-week-old male mice were used as young controls. Sixteen-week-old male mice were untreated or subjected to desiccating stress with a fan alone or with a fan plus subcutaneous injections of the anticholinergic agent scopolamine for 5 or 10 days to inhibit tear production. Mice spontaneously developed Sjogren′s syndrome-like lacrimal keratoconjunctivitis as they aged. Desiccating stress increased CD4+ and CCR5+ cells and decreased CD8+ cells in the conjunctival epithelium and lacrimal gland. Intraepithelial gamma delta T cells significantly decreased after 5 days and returned to baseline levels after 10 days in both groups exposed to desiccating stress. These immunopathological changes were accompanied by a decrease in conjunctival goblet cell density. Greater matrix metalloproteinase-9 production, gelatinase activity and loss of epithelial cell membrane CD25 immunoreactivity was noted in the ocular surface epithelia of stressed mice. These findings indicate that desiccating environmental stress aggravates Sjogren′s syndrome-like lacrimal keratoconjunctivitis in the NOD mouse which has defective immunoregulation. (C) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000255834500003
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55153
专题北京大学第三临床医学院_眼科
作者单位1.Allergan Pharmaceut Inc, Irvine, CA 92623 USA
2.Peking Univ, Hosp 3, Ctr Eye, Beijing 100083, Peoples R China
3.Baylor Coll Med, Cullen Eye Inst, Dept Ophthalmol, Ocular Surface Ctr, Houston, TX 77030 USA
4.Chonnam Natl Univ, Sch Med, Dept Ophthalmol, Kwangju 501757, South Korea
推荐引用方式
GB/T 7714
Yoon, Kyung-Chul,De Paiva, Cintia S.,Qi, Hong,et al. Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice[J]. JOURNAL OF AUTOIMMUNITY,2008,30(4):212-221.
APA Yoon, Kyung-Chul.,De Paiva, Cintia S..,Qi, Hong.,Chen, Zhuo.,Farley, William J..,...&Pflugfelder, Stephen C..(2008).Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice.JOURNAL OF AUTOIMMUNITY,30(4),212-221.
MLA Yoon, Kyung-Chul,et al."Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice".JOURNAL OF AUTOIMMUNITY 30.4(2008):212-221.
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