IR@PKUHSC  > 北京大学第三临床医学院  > 耳鼻喉科
学科主题临床医学
Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC-ECD
Zhang, Ke; Li, Qian; Xu, Jia; Liu, Junxiu; Ke, Jia; Kang, Wei; Li, Tao; Ma, Furong
刊名ANALYST
2015
DOI10.1039/c5an00110b
140期:11页:3846-3851
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]PAROXYSMAL POSITIONAL VERTIGO ; MONOAMINE NEUROTRANSMITTERS ; VESTIBULOOCULAR REFLEX ; LIQUID-CHROMATOGRAPHY ; GUINEA-PIGS ; BRAIN ; RATS ; METABOLITES ; MANAGEMENT ; DISORDERS
英文摘要

Unilateral single semicircular canal occlusion (USSCO) is an effective treatment for some cases of intractable vertigo. All patients suffer behavioural imbalance caused by surgery, and then recover with a resumption of vestibular function. However, the compensation mechanism has not been fully evaluated. Findings suggest that serotonin (5-HT) is released from nerve terminals, and plays a vital role in the plasticity of the central nervous system. In this study, we performed surgery of unilateral single semicircular canal occlusion (USSCO) on guinea pigs, and investigated the change of 5-HT by in vivo microdialysis of the medial vestibular nucleus (MVN) coupled with high-performance liquid chromatography and electrochemical detection (HPLC-ECD). A total of 12 guinea pigs were divided randomly into two groups, namely the USSCO group and the control group. Animals in the USSCO group underwent surgery of lateral horizontal semicircular canal occlusion, and those in the control group experienced the same operation but just to expose the horizontal semicircular canal without occlusion. Vestibular disturbance symptoms were observed in the case of the USSCO group, e.g. head tilting, and forced circular movements and spontaneous nystagmus at postoperative days 1 and 3. The basal level of 5-HT was determined to be 316.78 +/- 16.62 nM. It elevated to 448.85 +/- 24.56 nM at one day following occlusion (P = 0.001). The increase was completely abolished with the vestibular dysfunction recovery. The results showed that unilateral horizontal semicircular canal occlusion could increase the 5-HT level in MVN. 5-HT may play a significant role in the process of central vestibular compensation with residual vestibular function.

语种英语
WOS记录号WOS:000354650300021
项目编号21272018 ; 91213305 ; 21372020 ; 21402004 ; 6245010 ; 6245006 ; 2011402303 ; 7112144
资助机构NSF of China ; Key Clinical Project from the Ministry of Health ; Key Clinical Project from the Peking University Third Hospital ; Capital Health Research and Development of Special Fund of China ; Beijing Science Foundation of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55155
专题北京大学第三临床医学院_耳鼻喉科
作者单位Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Ke,Li, Qian,Xu, Jia,et al. Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC-ECD[J]. ANALYST,2015,140(11):3846-3851.
APA Zhang, Ke.,Li, Qian.,Xu, Jia.,Liu, Junxiu.,Ke, Jia.,...&Ma, Furong.(2015).Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC-ECD.ANALYST,140(11),3846-3851.
MLA Zhang, Ke,et al."Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC-ECD".ANALYST 140.11(2015):3846-3851.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Ke]的文章
[Li, Qian]的文章
[Xu, Jia]的文章
百度学术
百度学术中相似的文章
[Zhang, Ke]的文章
[Li, Qian]的文章
[Xu, Jia]的文章
必应学术
必应学术中相似的文章
[Zhang, Ke]的文章
[Li, Qian]的文章
[Xu, Jia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。