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学科主题基础医学
Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets
He, ZP; Zhao, CH; Dong, QM; Zhuang, H; Song, SJ; Peng, G; Dwyer, DE
关键词SARS coronavirus lymphocytes CD4+and CD8+ lymphopenia
刊名INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
2005-11-01
DOI10.1016/j.ijid.2004.07.014
9期:6页:323-330
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]HONG-KONG ; OUTBREAK ; PNEUMONIA ; CHILDREN ; MEASLES
英文摘要

Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS.

Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals.

Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10(6)/L at day 7, and CD8+ cell count of 239 cells x 106 /L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia.

Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis. (c) 2005 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000233420700007
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55161
专题北京大学基础医学院_病原生物学系
作者单位1.Beijing Ditan Hosp, Beijing 100011, Peoples R China
2.Capital Univ Med Sci, Affiliated Beijing YouAn Hosp, Beijing 100054, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
4.Westmead Hosp, Ctr Infect Dis, Inst Clin Pathol & Med Res, Westmead, NSW 2145, Australia
5.Westmead Hosp, Microbiol Lab Serv, Inst Clin Pathol & Med Res, Westmead, NSW 2145, Australia
推荐引用方式
GB/T 7714
He, ZP,Zhao, CH,Dong, QM,et al. Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets[J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,2005,9(6):323-330.
APA He, ZP.,Zhao, CH.,Dong, QM.,Zhuang, H.,Song, SJ.,...&Dwyer, DE.(2005).Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets.INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,9(6),323-330.
MLA He, ZP,et al."Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets".INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 9.6(2005):323-330.
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