|Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets|
|He, ZP; Zhao, CH; Dong, QM; Zhuang, H; Song, SJ; Peng, G; Dwyer, DE|
|关键词||SARS coronavirus lymphocytes CD4+and CD8+ lymphopenia|
|刊名||INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES|
|WOS标题词||Science & Technology|
|关键词[WOS]||HONG-KONG ; OUTBREAK ; PNEUMONIA ; CHILDREN ; MEASLES|
Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS.
Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals.
Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10(6)/L at day 7, and CD8+ cell count of 239 cells x 106 /L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia.
Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis. (c) 2005 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
|作者单位||1.Beijing Ditan Hosp, Beijing 100011, Peoples R China|
2.Capital Univ Med Sci, Affiliated Beijing YouAn Hosp, Beijing 100054, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
4.Westmead Hosp, Ctr Infect Dis, Inst Clin Pathol & Med Res, Westmead, NSW 2145, Australia
5.Westmead Hosp, Microbiol Lab Serv, Inst Clin Pathol & Med Res, Westmead, NSW 2145, Australia
|He, ZP,Zhao, CH,Dong, QM,et al. Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets[J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,2005,9(6):323-330.|
|APA||He, ZP.,Zhao, CH.,Dong, QM.,Zhuang, H.,Song, SJ.,...&Dwyer, DE.(2005).Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets.INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,9(6),323-330.|
|MLA||He, ZP,et al."Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets".INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 9.6(2005):323-330.|
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