IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Clonal spread of carbapenem resistant Acinetobacter baumannii ST92 in a Chinese Hospital during a 6-year period
Huang, Lei; Sun, Liying; Yan, Yan
关键词Acinetobacter Baumannii Carbapenem Resistance Multilocus Sequence Typing (Mlst) Clonal Spread
刊名JOURNAL OF MICROBIOLOGY
2013-02-01
DOI10.1007/s12275-013-2341-4
51期:1页:113-117
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology
资助者Wellcome Trust ; Peking University First Hospital ; Wellcome Trust ; Peking University First Hospital
研究领域[WOS]Microbiology
关键词[WOS]FIELD GEL-ELECTROPHORESIS ; SEQUENCE TYPING SCHEME ; MOLECULAR EPIDEMIOLOGY ; BETA-LACTAMASE ; EFFLUX PUMP ; STRAIN
英文摘要

The carbapenem resistance rate of Acinetobacter baumannii in our hospital has increased steadily since 2004. The molecular epidemiology of carbapenem resistant A. baumannii (CRAB) clinical isolates was characterized by multilocus sequence typing (MLST) and rep-PCR in parallel, with pan-drug susceptible A. baumannii (PSAB) used as control. MLST was performed to determine the sequence types (STs), and eBURST algorithm was used to analyze their relatedness. Carbapenem resistance related genes (oxa-23, oxa-24, oxa-51, oxa-58, imp, vim, and adeB) were screened using Polymerase Chain Reaction (PCR) method. 23 STs were identified in the 65 included isolates, with ST92 being the predominant clone. PSAB clustered into more singletons than CRAB. The positivity of oxa-23 and adeB correlated with high level carbapenem resistance (MICIPM > 32 mg/L, MICMEM > 32 mg/L) of CRAB ST92 isolates in 2009, which was different from the resistance pattern (MIC(IPM)a parts per thousand currency sign4 mg/L, 8 mg/L a parts per thousand currency signMIC(MEM)a parts per thousand currency sign16 mg/L) of CRAB ST92 isolates in 2004. These observations suggest that clonal spread of CRAB ST92 isolates longitudinally is the possible reason for carbapenem resistance rate increase and correlate with high level carbapenem resistance in our hospital.

语种英语
所属项目编号201197 0006
资助者Wellcome Trust ; Peking University First Hospital ; Wellcome Trust ; Peking University First Hospital
WOS记录号WOS:000315581700015
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55163
专题北京大学第一临床医学院
作者单位Peking Univ, Dept Clin Lab, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Huang, Lei,Sun, Liying,Yan, Yan. Clonal spread of carbapenem resistant Acinetobacter baumannii ST92 in a Chinese Hospital during a 6-year period[J]. JOURNAL OF MICROBIOLOGY,2013,51(1):113-117.
APA Huang, Lei,Sun, Liying,&Yan, Yan.(2013).Clonal spread of carbapenem resistant Acinetobacter baumannii ST92 in a Chinese Hospital during a 6-year period.JOURNAL OF MICROBIOLOGY,51(1),113-117.
MLA Huang, Lei,et al."Clonal spread of carbapenem resistant Acinetobacter baumannii ST92 in a Chinese Hospital during a 6-year period".JOURNAL OF MICROBIOLOGY 51.1(2013):113-117.
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