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学科主题药学
Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594
Zhang, CX; Ge, ZM; Cheng, TM; Li, RT
关键词Nicotinic Cholinergic Receptor Analgesic Activity Highly Sterically Hindered Secondary Amine Analogues Of pyridylmethylAmine Synthesis
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2006-04-01
DOI10.1016/j.bmcl.2005.12.073
16期:7页:2013-2016
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]NICOTINIC ACETYLCHOLINE-RECEPTORS ; POISON FROG ; EPIBATIDINE ; AFFINITY ; AGONISTS ; BINDING ; LIGANDS ; POTENT ; AGENT
英文摘要

A series of highly sterically hindered secondary amine analogues of pyridylinethylamine (7a-f, 8a-c) and positional isomeric analogues of ABT-594 (9a-c) were synthesized and evaluated for their in vivo analgesic activity. The compounds 7a and 7d show potent analgesic activity and lower toxicity. Some interesting structure-activity relationships have been revealed. (C) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000236402500052
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55165
Collection北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Zhang, CX,Ge, ZM,Cheng, TM,et al. Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(7):2013-2016.
APA Zhang, CX,Ge, ZM,Cheng, TM,&Li, RT.(2006).Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(7),2013-2016.
MLA Zhang, CX,et al."Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.7(2006):2013-2016.
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