IR@PKUHSC  > 北京大学药学院
学科主题药学
Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594
Zhang, CX; Ge, ZM; Cheng, TM; Li, RT
关键词Nicotinic Cholinergic Receptor Analgesic Activity Highly Sterically Hindered Secondary Amine Analogues Of pyridylmethylAmine Synthesis
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2006-04-01
DOI10.1016/j.bmcl.2005.12.073
16期:7页:2013-2016
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]NICOTINIC ACETYLCHOLINE-RECEPTORS ; POISON FROG ; EPIBATIDINE ; AFFINITY ; AGONISTS ; BINDING ; LIGANDS ; POTENT ; AGENT
英文摘要

A series of highly sterically hindered secondary amine analogues of pyridylinethylamine (7a-f, 8a-c) and positional isomeric analogues of ABT-594 (9a-c) were synthesized and evaluated for their in vivo analgesic activity. The compounds 7a and 7d show potent analgesic activity and lower toxicity. Some interesting structure-activity relationships have been revealed. (C) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000236402500052
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55165
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, CX,Ge, ZM,Cheng, TM,et al. Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(7):2013-2016.
APA Zhang, CX,Ge, ZM,Cheng, TM,&Li, RT.(2006).Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(7),2013-2016.
MLA Zhang, CX,et al."Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.7(2006):2013-2016.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, CX]的文章
[Ge, ZM]的文章
[Cheng, TM]的文章
百度学术
百度学术中相似的文章
[Zhang, CX]的文章
[Ge, ZM]的文章
[Cheng, TM]的文章
必应学术
必应学术中相似的文章
[Zhang, CX]的文章
[Ge, ZM]的文章
[Cheng, TM]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。