北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 北京大学衰老研究中心  > 期刊论文
学科主题: 基础医学
题名:
SAHF: a new biomarker of cellular senescence
作者: Li Qian; Ma Li-Wei; Zhang Zong-Yu; Tong Tan-Jun
关键词: SAHF ; aging ; p16(INK4a)/Rb ; HMGA ; E2F
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2007-11-01
卷: 34, 期:11, 页:1123-1128
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: HUMAN-DIPLOID FIBROBLAST ; RETINOBLASTOMA PROTEIN ; P16(INK4A) EXPRESSION ; CULTURE ; DELAY
英文摘要:

The remodeling of chromatin is a key step in controlling and regulating the temporal expression of genes. In the senescent human diploid fibroblast, there is a specific heterochromatic structure accumulating in the nucleus in the form of punctate foci, which is termed as senescence-associated heterochromatic foci (SAHF). The histone H3 methylated on lysine 9 (K9M-H3) and Heterochromatin Protein 1 (HP1) are the marker proteins of SAHF. During the process of SAHF formation, many factors such as p 16(INK4a)/Rb pathway and HMGA proteins play a very important role. Recent studies have shown that SAHF may suppress the expression of some E2F-target genes, thereby making the cell keep in a stable senescent state. The discovery of SAHF has provided a new biomarker for the research of cellular senescence, and it also gives us a molecular explanation for the stability of the senescent state.

语种: 中文
WOS记录号: WOS:000251022800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55167
Appears in Collections:基础医学院_北京大学衰老研究中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Res Ctr Aging, Beijing 100083, Peoples R China

Recommended Citation:
Li Qian,Ma Li-Wei,Zhang Zong-Yu,et al. SAHF: a new biomarker of cellular senescence[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2007,34(11):1123-1128.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li Qian]'s Articles
[Ma Li-Wei]'s Articles
[Zhang Zong-Yu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li Qian]‘s Articles
[Ma Li-Wei]‘s Articles
[Zhang Zong-Yu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace