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学科主题: 基础医学
题名:
SAHF: a new biomarker of cellular senescence
作者: Li Qian; Ma Li-Wei; Zhang Zong-Yu; Tong Tan-Jun
关键词: SAHF ; aging ; p16(INK4a)/Rb ; HMGA ; E2F
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2007-11-01
卷: 34, 期:11, 页:1123-1128
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: HUMAN-DIPLOID FIBROBLAST ; RETINOBLASTOMA PROTEIN ; P16(INK4A) EXPRESSION ; CULTURE ; DELAY
英文摘要:

The remodeling of chromatin is a key step in controlling and regulating the temporal expression of genes. In the senescent human diploid fibroblast, there is a specific heterochromatic structure accumulating in the nucleus in the form of punctate foci, which is termed as senescence-associated heterochromatic foci (SAHF). The histone H3 methylated on lysine 9 (K9M-H3) and Heterochromatin Protein 1 (HP1) are the marker proteins of SAHF. During the process of SAHF formation, many factors such as p 16(INK4a)/Rb pathway and HMGA proteins play a very important role. Recent studies have shown that SAHF may suppress the expression of some E2F-target genes, thereby making the cell keep in a stable senescent state. The discovery of SAHF has provided a new biomarker for the research of cellular senescence, and it also gives us a molecular explanation for the stability of the senescent state.

语种: 中文
WOS记录号: WOS:000251022800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55167
Appears in Collections:基础医学院_北京大学衰老研究中心_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Res Ctr Aging, Beijing 100083, Peoples R China

Recommended Citation:
Li Qian,Ma Li-Wei,Zhang Zong-Yu,et al. SAHF: a new biomarker of cellular senescence[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2007,34(11):1123-1128.
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