学科主题基础医学
SAHF: a new biomarker of cellular senescence
Li Qian; Ma Li-Wei; Zhang Zong-Yu; Tong Tan-Jun
关键词Sahf Aging P16(Ink4a)/rb Hmga E2f
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
2007-11-01
34期:11页:1123-1128
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]HUMAN-DIPLOID FIBROBLAST ; RETINOBLASTOMA PROTEIN ; P16(INK4A) EXPRESSION ; CULTURE ; DELAY
英文摘要

The remodeling of chromatin is a key step in controlling and regulating the temporal expression of genes. In the senescent human diploid fibroblast, there is a specific heterochromatic structure accumulating in the nucleus in the form of punctate foci, which is termed as senescence-associated heterochromatic foci (SAHF). The histone H3 methylated on lysine 9 (K9M-H3) and Heterochromatin Protein 1 (HP1) are the marker proteins of SAHF. During the process of SAHF formation, many factors such as p 16(INK4a)/Rb pathway and HMGA proteins play a very important role. Recent studies have shown that SAHF may suppress the expression of some E2F-target genes, thereby making the cell keep in a stable senescent state. The discovery of SAHF has provided a new biomarker for the research of cellular senescence, and it also gives us a molecular explanation for the stability of the senescent state.

语种中文
WOS记录号WOS:000251022800001
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55167
专题北京大学基础医学院_北京大学衰老研究中心
作者单位Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Res Ctr Aging, Beijing 100083, Peoples R China
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GB/T 7714
Li Qian,Ma Li-Wei,Zhang Zong-Yu,et al. SAHF: a new biomarker of cellular senescence[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2007,34(11):1123-1128.
APA Li Qian,Ma Li-Wei,Zhang Zong-Yu,&Tong Tan-Jun.(2007).SAHF: a new biomarker of cellular senescence.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,34(11),1123-1128.
MLA Li Qian,et al."SAHF: a new biomarker of cellular senescence".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 34.11(2007):1123-1128.
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