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学科主题: 药学
题名:
CD38/cADPR/Ca2+ Pathway Promotes Cell Proliferation and Delays Nerve Growth Factor-induced Differentiation in PC12 Cells
作者: Yue, Jianbo1; Wei, Wenjie1; Lam, Connie M. C.1; Zhao, Yong-Juan1; Dong, Min2; Zhang, Liang-Ren2; Zhang, Li-He2; Lee, Hon-Cheung1
刊名: JOURNAL OF BIOLOGICAL CHEMISTRY
发表日期: 2009-10-23
DOI: 10.1074/jbc.M109.049767
卷: 284, 期:43, 页:29335-29342
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: CYCLIC-ADP-RIBOSE ; EMBRYONAL CARCINOMA-CELLS ; MEDIATED NEURONAL DIFFERENTIATION ; ADENOSINE-DIPHOSPHORIBOSE CADPR ; MUSCARINIC RECEPTOR ACTIVATION ; ADENINE-DINUCLEOTIDE PHOSPHATE ; CDK INHIBITOR P21(WAF1/CIP1) ; ARTERIAL SMOOTH-MUSCLE ; INDUCED CA2+ RELEASE ; NEURITE OUTGROWTH
英文摘要:

Intracellular Ca2+ mobilization plays an important role in a wide variety of cellular processes, and multiple second messengers are responsible for mediating intracellular Ca2+ changes. Here we explored the role of one endogenous Ca2+-mobilizing nucleotide, cyclic adenosine diphosphoribose (cADPR), in the proliferation and differentiation of neurosecretory PC12 cells. We found that cADPR induced Ca2+ release in PC12 cells and that CD38 is the main ADP-ribosyl cyclase responsible for the acetylcholine (ACh)-induced cADPR production in PC12 cells. In addition, the CD38/cADPR signaling pathway is shown to be required for the ACh-induced Ca2+ increase and cell proliferation. Inhibition of the pathway, on the other hand, accelerated nerve growth factor (NGF)-induced neuronal differentiation in PC12 cells. Conversely, overexpression of CD38 increased cell proliferation but delayed NGF-induced differentiation. Our data indicate that cADPR plays a dichotomic role in regulating proliferation and neuronal differentiation of PC12 cells.

语种: 英语
所属项目编号: N_HKU 722/08 ; 20831160506 ; 90713005
项目资助者: Research Grant Council (RGC) grants from Hong Kong ; National Natural Science Foundation of China (NSFC)/RGC ; Leukemia and Lymphoma Society of America
WOS记录号: WOS:000270896800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55168
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Univ Hong Kong, Dept Physiol, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 10019, Peoples R China

Recommended Citation:
Yue, Jianbo,Wei, Wenjie,Lam, Connie M. C.,et al. CD38/cADPR/Ca2+ Pathway Promotes Cell Proliferation and Delays Nerve Growth Factor-induced Differentiation in PC12 Cells[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2009,284(43):29335-29342.
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