IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells
Zhang, Yanfei1; Wang, Ji-Yang2,3,4; Han, Wenling1
关键词B-1a BCR expression cell death CMTM7 natural IgM
刊名INTERNATIONAL IMMUNOLOGY
2014
DOI10.1093/intimm/dxt042
26期:1页:47-57
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Immunology
关键词[WOS]DEFICIENT MICE ; MARGINAL ZONE ; PRONE MICE ; B1B CELLS ; B-CELLS ; AUTOIMMUNITY ; LYMPHOCYTES ; RESPONSES ; SELECTION ; CLONING
英文摘要

B-1 cells are an important cell population for the production of natural antibodies and front-line host defense. Here, we show that the MARVEL-domain-containing membrane protein CMTM7 (CKLF-like MARVEL transmembrane domain-containing 7) plays a critical role in BCR expression and survival in B-1a cells. We analyzed lymphocyte development in Rag1(-/-) mice reconstituted with Cmtm7(flox/+) fetal liver cells because of the unexpected lethality of the Cmtm7(flox/+) heterozygotes. We found a mild reduction of serum IgM and a significantly reduced B-1a population in the peritoneal cavity of Rag1(-/-) mice reconstituted with Cmtm7(flox/+) cells compared with those reconstituted with wild-type (WT) cells. The reduction of B-1a cells in Cmtm7(flox/+) mice was associated with reduced BCR expression and increased spontaneous cell death in these cells. In addition, both B-1a and B-1b cells derived from Cmtm7(flox/+) fetal liver cells contained a lower frequency of cells capable of spontaneously differentiating into IgM-secreting plasma cells than did those derived from WT fetal liver cells. Furthermore, Cmtm7(flox/+) B-1a and B-1b cells responded poorly to LPS-induced proliferation. In striking contrast to the defects in B-1 cells, Cmtm7(flox/+) B-2 cells did not show obvious abnormalities when compared with WT B-2 cells. These results demonstrate a specific role for CMTM7 in BCR expression and survival in B-1a cells.

语种英语
所属项目编号81273207
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000331121100005
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55170
Collection北京大学基础医学院_免疫学系
作者单位1.Shanghai Med Coll, Dept Immunol, Shanghai 200032, Peoples R China
2.Peking Univ, Key Lab Med Immunol, Sch Basic Med Sci,Minist Hlth, Hlth Sci Ctr,Ctr Human Dis Genom,Dept Immunol, Beijing 100191, Peoples R China
3.RIKEN, Yokohama Inst, Res Ctr Allergy & Immunol, Lab Immune Divers, Yokohama, Kanagawa 2300045, Japan
4.Tokyo Med & Dent Univ, Med Res Inst, Dept Immunol, Tokyo 1138510, Japan
Recommended Citation
GB/T 7714
Zhang, Yanfei,Wang, Ji-Yang,Han, Wenling. A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells[J]. INTERNATIONAL IMMUNOLOGY,2014,26(1):47-57.
APA Zhang, Yanfei,Wang, Ji-Yang,&Han, Wenling.(2014).A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells.INTERNATIONAL IMMUNOLOGY,26(1),47-57.
MLA Zhang, Yanfei,et al."A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells".INTERNATIONAL IMMUNOLOGY 26.1(2014):47-57.
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