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学科主题: 药学
题名:
MicroRNA Profiling in Chinese Patients with Primary Sjogren Syndrome Reveals Elevated miRNA-181a in Peripheral Blood Mononuclear Cells
作者: Peng, Linyi1,2,3,5; Ma, Weizhi4; Yi, Fan4; Yang, Yun-Jiao1,2,3,5; Lin, Wei1,2,3,5; Chen, Hua1,2,3,5; Zhang, Xuan1,2,3,5; Zhang, Li-He4; Zhang, Fengchun1,2,3,5; Du, Quan4
关键词: SJOGREN SYNDROME ; MICRORNA-181A ; T CELL MATURATION
刊名: JOURNAL OF RHEUMATOLOGY
发表日期: 2014-11-01
DOI: 10.3899/jrheum.131154
卷: 41, 期:11, 页:2208-2213
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: CLASSIFICATION CRITERIA ; EXPRESSION ; PATHOGENESIS ; DISEASE
英文摘要:

Objective. Characterized by chronic inflammation, dysfunction of exocrine glands, and systemic autoimmunity, primary Sjogren syndrome (pSS) is a common autoimmune disease in elderly women. Our study was performed to explore the potential involvement of microRNA (miRNA) in Chinese patients with pSS.

Methods. Using microarrays, miRNA expression in peripheral blood mononuclear cells (PBMC) was profiled in 4 female patients with pSS and 3 healthy participants, followed by a large-scale study of 33 patients and 10 healthy individuals. Compared to the healthy participants, 202 miRNA were upregulated and 180 were downregulated in the patients with pSS. To confirm this finding, a set of regulated miRNA was further examined in a large patient group, using quantitative reverse transcriptase-PCR assays.

Results. MiR-181a was the miRNA that most profoundly differed between patients with pSS and healthy individuals; however, similar miRNA-181a expression profiles were found in groups with different disease phenotypes. Together, these observations suggested that an elevated miRNA-181a level is a general phenomenon in Chinese patients with pSS.

Conclusion. In addition to the elevated miR-181a levels, our study led to the speculation that elevated miR-181a levels in the PBMC of these patients compromise the maturation of B cells, enabling them to recognize and attack autoantigens and resulting in disease phenotypes. In addition to the regulation of human miRNA, many virus-derived miRNA were unexpectedly upregulated in the patients with pSS, suggesting that viral infection of PBMC plays a role in this disease.

语种: 英语
所属项目编号: 2011CBA01102 ; 2011AA020111 ; 2008BAI59B03 ; 201202004 ; 5132015 ; 2012AA022501 ; 2011B090400478
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China ; National Science Technology Pillar Program in the 11th Five-Year Plan ; Special Research Fund for Public Welfare and the Health Industry ; Beijing Natural Science Foundation ; National High-tech R&amp ; D Program of China ; Guangdong Department of Science and Technology
WOS记录号: WOS:000344598900019
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55177
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing, Peoples R China
2.Chinese Acad Med Sci, Beijing 100730, Peoples R China
3.Peking Union Med Coll, Beijing 100021, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
5.Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing, Peoples R China

Recommended Citation:
Peng, Linyi,Ma, Weizhi,Yi, Fan,et al. MicroRNA Profiling in Chinese Patients with Primary Sjogren Syndrome Reveals Elevated miRNA-181a in Peripheral Blood Mononuclear Cells[J]. JOURNAL OF RHEUMATOLOGY,2014,41(11):2208-2213.
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