IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Phylogenetic Findings Suggest Possible New Habitat and Routes of Infection of Human Eumyctoma
de Hoog, G. Sybren1,2,3,4; Ahmed, Sarah A.1,2,5; Najafzadeh, Mohammad J.6,7; Sutton, Deanna A.8; Keisari, Maryam Saradeghi1; Fahal, Ahmed H.9; Eberhardt, Ursala1; Verkleij, Gerard J.1; Xin, Lian10; Stielow, Benjamin1; van de Sande, Wendy W. J.11
刊名PLOS NEGLECTED TROPICAL DISEASES
2013-05-01
DOI10.1371/journal.pntd.0002229
7期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Parasitology ; Tropical Medicine
研究领域[WOS]Infectious Diseases ; Parasitology ; Tropical Medicine
关键词[WOS]MADURELLA-MYCETOMATIS ; CHAETOMIUM-GLOBOSUM ; MAXIMUM-LIKELIHOOD ; MIXED MODELS ; PHEOHYPHOMYCOSIS ; ONYCHOMYCOSIS ; EUMYCETOMA ; AGENTS
英文摘要

Eumycetoma is a traumatic fungal infection in tropical and subtropical areas that may lead to severe disability. Madurella mycetomatis is one of the prevalent etiologic agents in arid Northeastern Africa. The source of infection has not been clarified. Subcutaneous inoculation from plant thorns has been hypothesized, but attempts to detect the fungus in relevant material have remained unsuccessful. The present study aims to find clues to reveal the natural habitat of Madurella species using a phylogenetic approach, i.e. by comparison of neighboring taxa with known ecology. Four species of Madurella were included in a large data set of species of Chaetomium, Chaetomidium, Thielavia, and Papulaspora (n = 128) using sequences of the universal fungal barcode gene rDNA ITS and the partial LSU gene sequence. Our study demonstrates that Madurella species are nested within the Chaetomiaceae, a family of fungi that mainly inhabit animal dung, enriched soil, and indoor environments. We hypothesize that cattle dung, ubiquitously present in rural East Africa, plays a significant role in the ecology of Madurella. If cow dung is an essential factor in inoculation by Madurella, preventative measures may involve the use of appropriate footwear in addition to restructuring of villages to reduce the frequency of contact with etiologic agents of mycetoma. On the other hand, the Chaetomiaceae possess a hidden clinical potential which needs to be explored.

语种英语
WOS记录号WOS:000319994400032
项目编号916.11.178
资助机构Netherlands Society of Scientific Research (NWO) ; Royal Netherlands Academy of Arts and Sciences
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55181
专题北京大学第一临床医学院_皮肤性病科
作者单位1.KNAW Fungal Biodivers Ctr, CBS Cent Bur Schimmelcultures, Utrecht, Netherlands
2.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
3.Sun Yat Sen Univ, Affiliated Hosp 2, Dept Dermatol, Guangzhou 510275, Guangdong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
5.Univ Khartoum, Dept Med Microbiol, Fac Med Lab Sci, Khartoum, Sudan
6.Mashhad Univ Med Sci, Dept Parasitol & Mycol, Ghaem Hosp, Sch Med, Mashhad, Iran
7.Mashhad Univ Med Sci, Canc Mol Pathol Res Ctr, Ghaem Hosp, Sch Med, Mashhad, Iran
8.Univ Texas Hlth Sci Ctr San Antonio, Fungus Testing Lab, Dept Pathol, San Antonio, TX 78229 USA
9.Univ Khartoum, Mycetoma Res Ctr, Khartoum, Sudan
10.Huazhong Sci & Technol Univ, Dept Dermatol & Venereol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China
11.Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
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de Hoog, G. Sybren,Ahmed, Sarah A.,Najafzadeh, Mohammad J.,et al. Phylogenetic Findings Suggest Possible New Habitat and Routes of Infection of Human Eumyctoma[J]. PLOS NEGLECTED TROPICAL DISEASES,2013,7(5).
APA de Hoog, G. Sybren.,Ahmed, Sarah A..,Najafzadeh, Mohammad J..,Sutton, Deanna A..,Keisari, Maryam Saradeghi.,...&van de Sande, Wendy W. J..(2013).Phylogenetic Findings Suggest Possible New Habitat and Routes of Infection of Human Eumyctoma.PLOS NEGLECTED TROPICAL DISEASES,7(5).
MLA de Hoog, G. Sybren,et al."Phylogenetic Findings Suggest Possible New Habitat and Routes of Infection of Human Eumyctoma".PLOS NEGLECTED TROPICAL DISEASES 7.5(2013).
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