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学科主题临床医学
Improving the clinical outcome of unmanipulated haploidentical blood and marrow transplantation
Chang, Y-J1; Huang, X-J1,2
刊名BONE MARROW TRANSPLANTATION
2015-06-01
DOI10.1038/bmt.2015.90
suppl.2页:S21-S23
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]STEM-CELL TRANSPLANTATION ; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE ; HEMATOLOGIC MALIGNANCIES ; IMMUNE RECONSTITUTION ; DONOR TRANSPLANTATION ; HEMATOPOIETIC SCT ; ACUTE-LEUKEMIA ; RELAPSE ; DEPLETION ; DISEASE
英文摘要

Unmanipulated haploidentical blood and marrow transplantation (HBMT) has been one of the most applied haploidentical transplant protocol, which offers rapid immune recovery, desirable health-related quality of life and comparable survival rate with those who received HLA-identical sibling transplantation or HLA-matched unrelated donor transplantation. Compared with HLA-identical sibling recipients, HBMT recipients experienced a lower risk of late effects. The HBMT protocol also shows superior in treating pediatric hematological maliganancies compared with unmbilical cord blood transplantation and could be successfully used as a post-remission treatment algorithm for adults acute myeloid leukemia with unfavorable cytogenetics. Several approaches, including optimal dose investigation of anti-thymocyte globulin, selecting the best donor, and modified donor lymphocyte infusion, have been designed to improve transplant outcomes.

语种英语
WOS记录号WOS:000356012900005
项目编号81230013 ; 2013AA020104
资助机构Key Program of National Natural Science Foundation of China ; Chang Jiang Scholars Program, Hi-Tech Research and Development Program of China ; Collaborative Innovation Center of Hematology, China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55184
专题北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Chang, Y-J,Huang, X-J. Improving the clinical outcome of unmanipulated haploidentical blood and marrow transplantation[J]. BONE MARROW TRANSPLANTATION,2015,suppl.2:S21-S23.
APA Chang, Y-J,&Huang, X-J.(2015).Improving the clinical outcome of unmanipulated haploidentical blood and marrow transplantation.BONE MARROW TRANSPLANTATION,suppl.2,S21-S23.
MLA Chang, Y-J,et al."Improving the clinical outcome of unmanipulated haploidentical blood and marrow transplantation".BONE MARROW TRANSPLANTATION suppl.2(2015):S21-S23.
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