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学科主题: 临床医学
题名:
Improving the clinical outcome of unmanipulated haploidentical blood and marrow transplantation
作者: Chang, Y-J1; Huang, X-J1,2
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2015-06-01
DOI: 10.1038/bmt.2015.90
卷: suppl.2, 页:S21-S23
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: STEM-CELL TRANSPLANTATION ; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE ; HEMATOLOGIC MALIGNANCIES ; IMMUNE RECONSTITUTION ; DONOR TRANSPLANTATION ; HEMATOPOIETIC SCT ; ACUTE-LEUKEMIA ; RELAPSE ; DEPLETION ; DISEASE
英文摘要:

Unmanipulated haploidentical blood and marrow transplantation (HBMT) has been one of the most applied haploidentical transplant protocol, which offers rapid immune recovery, desirable health-related quality of life and comparable survival rate with those who received HLA-identical sibling transplantation or HLA-matched unrelated donor transplantation. Compared with HLA-identical sibling recipients, HBMT recipients experienced a lower risk of late effects. The HBMT protocol also shows superior in treating pediatric hematological maliganancies compared with unmbilical cord blood transplantation and could be successfully used as a post-remission treatment algorithm for adults acute myeloid leukemia with unfavorable cytogenetics. Several approaches, including optimal dose investigation of anti-thymocyte globulin, selecting the best donor, and modified donor lymphocyte infusion, have been designed to improve transplant outcomes.

语种: 英语
所属项目编号: 81230013 ; 2013AA020104
项目资助者: Key Program of National Natural Science Foundation of China ; Chang Jiang Scholars Program, Hi-Tech Research and Development Program of China ; Collaborative Innovation Center of Hematology, China
WOS记录号: WOS:000356012900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55184
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

Recommended Citation:
Chang, Y-J,Huang, X-J. Improving the clinical outcome of unmanipulated haploidentical blood and marrow transplantation[J]. BONE MARROW TRANSPLANTATION,2015,suppl.2:S21-S23.
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