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Effect of Marine Collagen Peptides on Markers of Metabolic Nuclear Receptors in Type 2 Diabetic Patients with/without Hypertension
Zhu, Cui-Feng1,2; Li, Guan-Zhi2; Peng, Hong-Bin1; Zhang, Fan3; Chen, Yun4; Li, Yong1
关键词Marine Collagen Peptide Peroxisome Proliferator-activated Receptor (Ppar) Liver x Receptor Farnesoid x Receptor Metabolic Nuclear Receptor
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
2010-04-01
23期:2页:113-120
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]CORONARY-ARTERY-DISEASE ; GLUCOSE-TOLERANCE ; BLOOD-PRESSURE ; INSULIN ACTION ; X-RECEPTOR ; ADIPONECTIN ; MELLITUS ; PROTEIN ; CHINA ; LIVER
英文摘要

Objective To explore Effects of marine collagen peptides (MCPs) on markers of metablic nuclear receptors, i.e peroxisome proliferator-activated receptor (PPARs), liver X receptor (LXRs) and farnesoid X receptor (FXRs) in type 2 diabetic patients with/without hypertension. Method Study population consisted of 200 type 2 diabetic patients with/without hypertension and 50 healthy subjects, all of whom were randomly assigned to MCPs-treated diabetics (n=50), placebo-treated diabetics (n=50), MCPs-treated diabetics with hypertension (n=50), placebo-treated diabetics with hypertension (n=50), and healthy controls (n=50). MCPs or placebo (water-soluble starch) were given daily before breakfast and bedtime over three months. Levels of free fatty acid, cytochrome P450, leptin, resistin, adiponectin, bradykinin, NO, and Prostacyclin were determined before intervention, and 1.5 months, and 3 months after intervention. Hypoglycemia and the endpoint events during the study were recorded and compared among the study groups. Result At the end of the study period, MCPs-treated patients showed marked improvement compared with patients receiving placebo. The protection exerted by MCPs seemed more profound in diabetics than in diabetics with hypertension. In particular, after MCPs intervention, levels of free fatty acid, hs-CRP, resistin, Prostacyclin decreased significantly in diabetics and tended to decrease in diabetic and hypertensive patients whereas levels of cytochrome P450, leptin, NO tended to decrease in diabetics with/without hypertension. Meanwhile, levels of adiponectin and bradykinin rose markedly in diabetics following MCPs administration. Conclusion MCPs could offer protection against diabetes and hypertension by affecting levels of molecules involved in diabetic and hypertensive pathogenesis. Regulation on metabolic nuclear receptors by MCPs may be the possible underlying mechanism for its observed effects in the study. Further study into its action may shed light on development of new drugs based on bioactive peptides from marine sources.

语种英语
WOS记录号WOS:000277802200005
项目编号2006BAD27B01 ; DIC-200710 ; 200802002
资助机构National Key Technology RD Program ; Chinese Center for Disease Control and Prevention Dalone Foundation of Dietary Nutrition ; Shenzhen Bureau of Science Technology Information
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55187
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 10083, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Nutr, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Endocrinol, Shenzhen 518036, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Ultrasound Div, Shenzhen 518036, Guangdong, Peoples R China
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GB/T 7714
Zhu, Cui-Feng,Li, Guan-Zhi,Peng, Hong-Bin,et al. Effect of Marine Collagen Peptides on Markers of Metabolic Nuclear Receptors in Type 2 Diabetic Patients with/without Hypertension[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2010,23(2):113-120.
APA Zhu, Cui-Feng,Li, Guan-Zhi,Peng, Hong-Bin,Zhang, Fan,Chen, Yun,&Li, Yong.(2010).Effect of Marine Collagen Peptides on Markers of Metabolic Nuclear Receptors in Type 2 Diabetic Patients with/without Hypertension.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,23(2),113-120.
MLA Zhu, Cui-Feng,et al."Effect of Marine Collagen Peptides on Markers of Metabolic Nuclear Receptors in Type 2 Diabetic Patients with/without Hypertension".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 23.2(2010):113-120.
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