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学科主题: 临床医学
题名:
Synthesis and antibacterial activity of 11,12-carbamate-3-O-acyl erythromycin derivatives
作者: Xu, Peng1; Liu, Lu1; He, Wei1; Li, Yun2; Liu, Jian2; Lei, Ping-Sheng1
关键词: macrolide ; acylide ; antibacterial activity ; resistant strains
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2009
DOI: 10.1080/10286020903176461
卷: 11, 期:10, 页:880-897
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: MACROLIDE ANTIBIOTICS ; RESISTANT ; ACYLIDES ; INHIBITORS ; PATHOGENS ; ANALOGS ; POTENT
英文摘要:

A novel series of acylide derivatives have been synthesized which exhibit in vitro potency against key respiratory pathogens. Modification of position 3 was accomplished by replacing different 3-O-substituted acyl groups in the macrolide core via a facile procedure. Compounds 7a-7i were eventually yielded by the conjunction of diverse hetero-aryl side chains with the 11-N,12-O-carbamate sub-structure.

语种: 英语
所属项目编号: 30572275 ; 7062047
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing
WOS记录号: WOS:000271181100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55189
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Mat Med, Peking Union Med Coll, Beijing 100050, Peoples R China
2.Peking Univ, Inst Clin Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Peng,Liu, Lu,He, Wei,et al. Synthesis and antibacterial activity of 11,12-carbamate-3-O-acyl erythromycin derivatives[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2009,11(10):880-897.
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