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学科主题: 药学
题名:
Two Prenylated and C-Methylated Flavonoids from Tripterygium wilfordii
作者: Zeng, Feng1,4; Wang, Wei2; Wu, Yunshan3; Dey, Moul4; Ye, Min1; Avery, Mitchell A.3; Khan, Ikhlas A.2; Guo, De-an1,5
关键词: Celastraceae ; Tripterygium wilfordii ; anti-inflammatory ; antiproliferation ; flavonoid ; C-methylflavone
刊名: PLANTA MEDICA
发表日期: 2010-10-01
DOI: 10.1055/s-0029-1241017
卷: 76, 期:14, 页:1596-1599
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: HOOK-F ; FLAVANONES ; CHEMISTRY ; CANCER ; ROOTS ; CELLS ; WAXES ; ACID
英文摘要:

Two unusual prenylated and C-methylated flavanones, (+/-)-5,4′-dihydroxy-2′-methoxy-6′, 6 ′′′-dimethypyrano-(2 ′′, 3 ′′: 7,8)-6-methyflavanone (1) and (2S)-5,7,4′-trihydroxy-2′-methoxy-8,5′- di(3-methyl-2-butenyl)-6-methyflavanone (2), and 10 known compounds were isolated from the stems and roots of Tripterygium wilfordii. Their structures were elucidated based on spectroscopic analyses including 1- and 2-D NMR, HR-ESI-MS, CD, and x-ray crystallography. The anti-inflammatory, antiproliferative, and antibacterial activities of compounds 1 and 2 were investigated. Compound 2 had an inhibitory effect on lipopolysaccharides (LPS)-triggered RAW cell nitric oxide (NO) production, with an IC(50) value of 15.0 +/- 0.7 mu M. Both compounds showed moderate antiproliferative activity against the tumor cell lines HT-29 and ZR-75-1.

语种: 英语
所属项目编号: 985-2-063-112 ; 104218
项目资助者: Changjiang Scholars and Innovation Team in University ; Ministry of Education of China
WOS记录号: WOS:000282366800019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55190
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Univ Mississippi, Pharmaceut Sci Res Inst, Sino US TCM Res Ctr, Natl Ctr Nat Prod Res, University, MS 38677 USA
3.Univ Mississippi, Dept Med Chem, University, MS 38677 USA
4.Rutgers State Univ, Biotech Ctr, New Brunswick, NJ 08903 USA
5.CAS, Shanghai Res Ctr Modernizat TCM, Shanghai Inst Mat Med, Shanghai, Peoples R China

Recommended Citation:
Zeng, Feng,Wang, Wei,Wu, Yunshan,et al. Two Prenylated and C-Methylated Flavonoids from Tripterygium wilfordii[J]. PLANTA MEDICA,2010,76(14):1596-1599.
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